Searched for:  IRF1

IRF1 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in IRF1 are not predicted modulate anything in gbmSYGNAL.
 

IRF1 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
IRF128
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
IRF1 (Rep.)PITA_1002.87 (4.1E-03)
IRF1 (Rep.)PITA_1502.60 (9.4E-03)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)PITA_2823.66 (2.5E-04)Tumor promoting inflammationSelf sufficiency in growth signalsEvading immune detectionInsensitivity to antigrowth signals
IRF1 (Rep.)PITA_3054.30 (1.7E-05)
IRF1 (Rep.)PITA_3783.76 (1.7E-04)
IRF1 (Rep.)PITA_4523.32 (8.9E-04)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)PITA_5942.40 (1.7E-02)
IRF1 (Rep.)TARGETSCAN_92.71 (6.7E-03)
IRF1 (Rep.)TARGETSCAN_123.61 (3.1E-04)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)TARGETSCAN_1032.71 (6.7E-03)
IRF1 (Rep.)TARGETSCAN_1733.33 (8.8E-04)
IRF1 (Rep.)TARGETSCAN_1884.78 (1.7E-06)
IRF1 (Rep.)TARGETSCAN_2883.89 (1.0E-04)
IRF1 (Rep.)TARGETSCAN_3393.19 (1.4E-03)
IRF1 (Rep.)TARGETSCAN_4174.17 (3.1E-05)
IRF1 (Rep.)TARGETSCAN_5334.20 (2.6E-05)
IRF1 (Rep.)TARGETSCAN_5413.29 (1.0E-03)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)TARGETSCAN_5762.81 (4.9E-03)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)TFBS_DB_434.00 (6.3E-05)
IRF1 (Rep.)TFBS_DB_1862.55 (1.1E-02)Tumor promoting inflammationSelf sufficiency in growth signalsEvading immune detectionInsensitivity to antigrowth signals
IRF1 (Rep.)TFBS_DB_2573.53 (4.1E-04)
IRF1 (Rep.)TFBS_DB_3263.28 (1.0E-03)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)TFBS_DB_4563.85 (1.2E-04)
IRF1 (Rep.)TFBS_DB_5073.70 (2.1E-04)
IRF1 (Rep.)TFBS_DB_5373.65 (2.6E-04)Tumor promoting inflammationEvading immune detection
IRF1 (Rep.)TFBS_DB_5592.93 (3.4E-03)
IRF1 (Rep.)TFBS_DB_5873.40 (6.8E-04)
IRF1 (Rep.)TFBS_DB_5893.21 (1.3E-03)Tumor promoting inflammationTissue invasion and metastasisEvading immune detection

Biclusters containing IRF1:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Not in any biclusters.