TFBS_DB_589

Bicluster Network Summary

Legend:
= Somatically mutated gene/pathway
= TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer

Summary

Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype.
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment.
GenesPatient TumorsFPC Var. Exp.
(Perm. p-value)
Survival
(p-value)
Independent Replication
35416
0.61 (0.0E+00)
3.21 (1.3E-03)
Co-expression
Survival
RegulatorsCausal FlowsEnriched GO BPsEnriched
Hallmarks of Cancer
1111793

Replication in independent datasets

StudyFPC Var. Exp. (Perm. p-value)Survival (p-value)
Gravendeel, et al. 2009
0.63 (0.0E+00)
3.19 (1.4E-03)
Madhavan, et al. 2009
0.68 (0.0E+00)
3.55 (3.8E-04)
Murat, et al. 2008
0.61 (0.0E+00)
-0.92 (3.6E-01)

Patients

  • TCGA.02.0001
  • TCGA.02.0003
  • TCGA.02.0004
  • TCGA.02.0006
  • TCGA.02.0007
  • TCGA.02.0009
  • TCGA.02.0010
  • TCGA.02.0011
  • TCGA.02.0014
  • TCGA.02.0015
  • TCGA.02.0016
  • TCGA.02.0021
  • TCGA.02.0023
  • TCGA.02.0024
  • TCGA.02.0025
  • TCGA.02.0026
  • TCGA.02.0027
  • TCGA.02.0028
  • TCGA.02.0033
  • TCGA.02.0034
  • TCGA.02.0037
  • TCGA.02.0038
  • TCGA.02.0039
  • TCGA.02.0043
  • TCGA.02.0046
  • TCGA.02.0047
  • TCGA.02.0048
  • TCGA.02.0051
  • TCGA.02.0052
  • TCGA.02.0054
  • TCGA.02.0055
  • TCGA.02.0057
  • TCGA.02.0058
  • TCGA.02.0059
  • TCGA.02.0060
  • TCGA.02.0064
  • TCGA.02.0068
  • TCGA.02.0069
  • TCGA.02.0070
  • TCGA.02.0071
  • TCGA.02.0074
  • TCGA.02.0075
  • TCGA.02.0079
  • TCGA.02.0080
  • TCGA.02.0083
  • TCGA.02.0085
  • TCGA.02.0086
  • TCGA.02.0089
  • TCGA.02.0099
  • TCGA.02.0102
  • TCGA.02.0104
  • TCGA.02.0107
  • TCGA.02.0113
  • TCGA.02.0114
  • TCGA.02.0115
  • TCGA.02.0116
  • TCGA.02.0289
  • TCGA.02.0321
  • TCGA.02.0330
  • TCGA.02.0332
  • TCGA.02.0337
  • TCGA.02.0422
  • TCGA.02.0430
  • TCGA.02.0432
  • TCGA.02.0440
  • TCGA.02.0446
  • TCGA.02.2466
  • TCGA.02.2470
  • TCGA.02.2483
  • TCGA.02.2485
  • TCGA.02.2486
  • TCGA.06.0122
  • TCGA.06.0124
  • TCGA.06.0125
  • TCGA.06.0126
  • TCGA.06.0128
  • TCGA.06.0129
  • TCGA.06.0130
  • TCGA.06.0132
  • TCGA.06.0133
  • TCGA.06.0137
  • TCGA.06.0138
  • TCGA.06.0139
  • TCGA.06.0140
  • TCGA.06.0141
  • TCGA.06.0142
  • TCGA.06.0143
  • TCGA.06.0145
  • TCGA.06.0146
  • TCGA.06.0148
  • TCGA.06.0150
  • TCGA.06.0151
  • TCGA.06.0152
  • TCGA.06.0154
  • TCGA.06.0155
  • TCGA.06.0156
  • TCGA.06.0157
  • TCGA.06.0158
  • TCGA.06.0159
  • TCGA.06.0160
  • TCGA.06.0165
  • TCGA.06.0166
  • TCGA.06.0167
  • TCGA.06.0168
  • TCGA.06.0169
  • TCGA.06.0171
  • TCGA.06.0173
  • TCGA.06.0174
  • TCGA.06.0176
  • TCGA.06.0178
  • TCGA.06.0184
  • TCGA.06.0185
  • TCGA.06.0187
  • TCGA.06.0188
  • TCGA.06.0189
  • TCGA.06.0190
  • TCGA.06.0192
  • TCGA.06.0195
  • TCGA.06.0197
  • TCGA.06.0201
  • TCGA.06.0206
  • TCGA.06.0208
  • TCGA.06.0209
  • TCGA.06.0210
  • TCGA.06.0211
  • TCGA.06.0213
  • TCGA.06.0214
  • TCGA.06.0216
  • TCGA.06.0219
  • TCGA.06.0221
  • TCGA.06.0237
  • TCGA.06.0238
  • TCGA.06.0240
  • TCGA.06.0241
  • TCGA.06.0394
  • TCGA.06.0409
  • TCGA.06.0644
  • TCGA.06.0649
  • TCGA.06.0650
  • TCGA.06.0673
  • TCGA.06.0675
  • TCGA.06.0676
  • TCGA.06.0678
  • TCGA.06.0681
  • TCGA.06.0686
  • TCGA.06.0743
  • TCGA.06.0744
  • TCGA.06.0745
  • TCGA.06.0747
  • TCGA.06.0749
  • TCGA.06.0750
  • TCGA.06.0875
  • TCGA.06.0876
  • TCGA.06.0877
  • TCGA.06.0878
  • TCGA.06.0879
  • TCGA.06.0881
  • TCGA.06.0882
  • TCGA.06.1084
  • TCGA.06.1086
  • TCGA.06.1087
  • TCGA.06.1800
  • TCGA.06.1801
  • TCGA.06.1802
  • TCGA.06.1804
  • TCGA.06.1805
  • TCGA.06.2557
  • TCGA.06.2558
  • TCGA.06.2559
  • TCGA.06.2561
  • TCGA.06.2562
  • TCGA.06.2563
  • TCGA.06.2564
  • TCGA.06.2565
  • TCGA.06.2566
  • TCGA.06.2567
  • TCGA.06.2570
  • TCGA.06.5412
  • TCGA.06.5414
  • TCGA.06.5415
  • TCGA.06.5417
  • TCGA.06.5418
  • TCGA.06.5856
  • TCGA.06.5859
  • TCGA.06.6388
  • TCGA.06.6390
  • TCGA.06.6695
  • TCGA.06.6697
  • TCGA.06.6698
  • TCGA.06.6699
  • TCGA.06.6701
  • TCGA.08.0244
  • TCGA.08.0245
  • TCGA.08.0246
  • TCGA.08.0344
  • TCGA.08.0346
  • TCGA.08.0347
  • TCGA.08.0348
  • TCGA.08.0350
  • TCGA.08.0351
  • TCGA.08.0353
  • TCGA.08.0354
  • TCGA.08.0355
  • TCGA.08.0356
  • TCGA.08.0357
  • TCGA.08.0359
  • TCGA.08.0360
  • TCGA.08.0380
  • TCGA.08.0385
  • TCGA.08.0389
  • TCGA.08.0390
  • TCGA.08.0392
  • TCGA.08.0510
  • TCGA.08.0512
  • TCGA.08.0517
  • TCGA.08.0524
  • TCGA.08.0623
  • TCGA.08.0625
  • TCGA.08.0626
  • TCGA.08.0627
  • TCGA.12.0616
  • TCGA.12.0618
  • TCGA.12.0619
  • TCGA.12.0620
  • TCGA.12.0653
  • TCGA.12.0654
  • TCGA.12.0656
  • TCGA.12.0657
  • TCGA.12.0662
  • TCGA.12.0670
  • TCGA.12.0688
  • TCGA.12.0691
  • TCGA.12.0692
  • TCGA.12.0703
  • TCGA.12.0707
  • TCGA.12.0769
  • TCGA.12.0772
  • TCGA.12.0773
  • TCGA.12.0775
  • TCGA.12.0776
  • TCGA.12.0778
  • TCGA.12.0780
  • TCGA.12.0818
  • TCGA.12.0819
  • TCGA.12.0820
  • TCGA.12.0821
  • TCGA.12.0822
  • TCGA.12.0826
  • TCGA.12.0827
  • TCGA.12.0828
  • TCGA.12.0829
  • TCGA.12.1088
  • TCGA.12.1089
  • TCGA.12.1091
  • TCGA.12.1092
  • TCGA.12.1093
  • TCGA.12.1094
  • TCGA.12.1095
  • TCGA.12.1097
  • TCGA.12.1098
  • TCGA.12.1099
  • TCGA.12.1599
  • TCGA.12.1600
  • TCGA.12.1602
  • TCGA.12.3646
  • TCGA.12.3649
  • TCGA.12.5295
  • TCGA.14.0736
  • TCGA.14.0781
  • TCGA.14.0783
  • TCGA.14.0787
  • TCGA.14.0789
  • TCGA.14.0790
  • TCGA.14.0812
  • TCGA.14.0813
  • TCGA.14.0817
  • TCGA.14.0865
  • TCGA.14.0867
  • TCGA.14.1034
  • TCGA.14.1037
  • TCGA.14.1043
  • TCGA.14.1396
  • TCGA.14.1401
  • TCGA.14.1402
  • TCGA.14.1450
  • TCGA.14.1451
  • TCGA.14.1452
  • TCGA.14.1453
  • TCGA.14.1454
  • TCGA.14.1456
  • TCGA.14.1458
  • TCGA.14.1459
  • TCGA.14.1827
  • TCGA.14.1829
  • TCGA.14.2554
  • TCGA.14.3476
  • TCGA.14.4157
  • TCGA.15.0742
  • TCGA.15.1446
  • TCGA.15.1447
  • TCGA.15.1449
  • TCGA.16.0846
  • TCGA.16.0848
  • TCGA.16.0849
  • TCGA.16.0850
  • TCGA.16.0861
  • TCGA.16.1045
  • TCGA.16.1047
  • TCGA.16.1055
  • TCGA.16.1056
  • TCGA.16.1060
  • TCGA.16.1062
  • TCGA.16.1063
  • TCGA.19.0955
  • TCGA.19.0957
  • TCGA.19.0960
  • TCGA.19.0963
  • TCGA.19.0964
  • TCGA.19.1387
  • TCGA.19.1390
  • TCGA.19.1392
  • TCGA.19.1787
  • TCGA.19.1790
  • TCGA.19.1791
  • TCGA.19.2619
  • TCGA.19.2625
  • TCGA.19.2629
  • TCGA.19.2631
  • TCGA.19.5947
  • TCGA.19.5951
  • TCGA.19.5953
  • TCGA.19.5954
  • TCGA.19.5955
  • TCGA.19.5956
  • TCGA.19.5959
  • TCGA.26.1438
  • TCGA.26.1439
  • TCGA.26.1440
  • TCGA.26.1442
  • TCGA.26.1443
  • TCGA.26.5133
  • TCGA.26.5134
  • TCGA.26.5135
  • TCGA.26.5136
  • TCGA.26.5139
  • TCGA.26.6173
  • TCGA.27.1833
  • TCGA.27.1836
  • TCGA.27.1837
  • TCGA.27.1838
  • TCGA.27.2518
  • TCGA.27.2519
  • TCGA.27.2521
  • TCGA.27.2523
  • TCGA.27.2526
  • TCGA.27.2527
  • TCGA.27.2528
  • TCGA.28.1745
  • TCGA.28.1746
  • TCGA.28.1747
  • TCGA.28.1751
  • TCGA.28.1753
  • TCGA.28.1755
  • TCGA.28.1756
  • TCGA.28.2506
  • TCGA.28.2509
  • TCGA.28.2510
  • TCGA.28.2513
  • TCGA.28.2514
  • TCGA.28.5208
  • TCGA.28.5209
  • TCGA.28.5213
  • TCGA.28.5214
  • TCGA.28.5220
  • TCGA.28.6450
  • TCGA.32.1970
  • TCGA.32.1973
  • TCGA.32.1976
  • TCGA.32.1982
  • TCGA.32.1986
  • TCGA.32.1987
  • TCGA.32.1991
  • TCGA.32.2491
  • TCGA.32.2494
  • TCGA.32.2495
  • TCGA.32.2615
  • TCGA.32.4208
  • TCGA.32.4209
  • TCGA.32.4210
  • TCGA.32.4211
  • TCGA.32.4719
  • TCGA.41.2572
  • TCGA.41.2573
  • TCGA.41.2575
  • TCGA.41.3393
  • TCGA.41.3915
  • TCGA.41.4097
  • TCGA.41.5651
  • TCGA.74.6573
  • TCGA.74.6575
  • TCGA.74.6578
  • TCGA.76.4925
  • TCGA.76.4927
  • TCGA.76.4932
  • TCGA.76.4934
  • TCGA.76.4935
  • TCGA.76.6191
  • TCGA.76.6282
  • TCGA.76.6286
  • TCGA.76.6657
  • TCGA.76.6660
  • TCGA.76.6661
  • TCGA.76.6664
  • TCGA.81.5910
  • TCGA.81.5911
  • TCGA.87.5896

Regulators

TypeNameActionPrior Knowledge
TFIRF1
Activator
Yes

Causal Flows

MutationRegulatorBicluster
CXCR3_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_589
EPHB_FORWARD_SIGNALINGIRF1TFBS_DB_589
ERBB2_ERBB3_SIGNALING_EVENTSIRF1TFBS_DB_589
ERBB4_SIGNALING_EVENTSIRF1TFBS_DB_589
GMCSF_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_589
IL23_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_589
IL2_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_589
IL2_SIGNALING_EVENTS_MEDIATED_BY_STAT5IRF1TFBS_DB_589
NEUROTROPHIC_FACTOR_MEDIATED_TRK_RECEPTOR_SIGNALINGIRF1TFBS_DB_589
SIGNALING_EVENTS_MEDIATED_BY_FOCAL_ADHESION_KINASEIRF1TFBS_DB_589
SIGNALING_EVENTS_REGULATED_BY_RET_TYROSINE_KINASEIRF1TFBS_DB_589

Enriched GO Biological Processes

GO TermGO BP IDGenes
Cell activationGO:0001775
B cell homeostasisGO:0001782LYN
Cytokine productionGO:0001816S100A8
Regulation of cytokine productionGO:0001817LYN
Positive regulation of protein phosphorylationGO:0001934AIF1
Response to molecule of bacterial originGO:0002237
Adaptive immune responseGO:0002250CLEC4A LILRB2 LYN SYK
Immune effector processGO:0002252
Activation of immune responseGO:0002253
Myeloid leukocyte activationGO:0002274
Myeloid cell activation involved in immune responseGO:0002275
Mast cell activation involved in immune responseGO:0002279
Immune system processGO:0002376
Immune response-activating cell surface receptor signaling pathwayGO:0002429
Fc receptor mediated stimulatory signaling pathwayGO:0002431FCER1G LYN
Leukocyte mediated immunityGO:0002443
Myeloid leukocyte mediated immunityGO:0002444
Mast cell mediated immunityGO:0002448
Lymphocyte mediated immunityGO:0002449
Humoral immune response mediated by circulating immunoglobulinGO:0002455
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460
Antigen processing and presentation of peptide antigen via mhc class iiGO:0002495
Tolerance inductionGO:0002507
Acute inflammatory responseGO:0002526ALOX5 S100A8
Production of molecular mediator involved in inflammatory responseGO:0002532
Arachidonic acid metabolite production involved in inflammatory responseGO:0002538
Leukotriene production involved in inflammatory responseGO:0002540ALOX5
Monocyte chemotaxisGO:0002548CCL2
Platelet degranulationGO:0002576LYN SERPING1 SRGN
Regulation of antigen processing and presentationGO:0002577
Regulation of immune system processGO:0002682
Negative regulation of immune system processGO:0002683
Positive regulation of immune system processGO:0002684
Regulation of leukocyte migrationGO:0002685
Positive regulation of leukocyte migrationGO:0002687TLR2
Regulation of leukocyte chemotaxisGO:0002688
Positive regulation of leukocyte chemotaxisGO:0002690
Regulation of leukocyte activationGO:0002694
Positive regulation of leukocyte activationGO:0002696
Regulation of immune effector processGO:0002697
Positive regulation of immune effector processGO:0002699
Positive regulation of cytokine production involved in immune responseGO:0002720
Immune response-activating signal transductionGO:0002757
Immune response-regulating signaling pathwayGO:0002764
Immune response-inhibiting signal transductionGO:0002765
Immune response-inhibiting cell surface receptor signaling pathwayGO:0002767LILRB2
Immune response-regulating cell surface receptor signaling pathwayGO:0002768LYN
Fc receptor mediated inhibitory signaling pathwayGO:0002774LILRB2 LYN
Regulation of myeloid leukocyte mediated immunityGO:0002886
Fatty acid biosynthetic processGO:0006633
Unsaturated fatty acid biosynthetic processGO:0006636
Icosanoid metabolic processGO:0006690
Leukotriene metabolic processGO:0006691ALOX5 ALOX5AP
ExocytosisGO:0006887
PhagocytosisGO:0006909
Phagocytosis, engulfmentGO:0006911AIF1 FCER1G
ChemotaxisGO:0006935CCL2
Response to stressGO:0006950
Defense responseGO:0006952CD74
Inflammatory responseGO:0006954AIF1 CCL2 CHI3L1 CYBB LY96 PSTPIP1 S100A8 TLR2
Immune responseGO:0006955FCGR2B LCP2 LILRB2 TLR2
Complement activationGO:0006956C1QB C1S
Complement activation, classical pathwayGO:0006958C1QB C1S SERPING1
Humoral immune responseGO:0006959CCL2
Blood coagulationGO:0007596AMICA1 CD74 FCER1G LCP2 LYN SERPING1 SRGN SYK
HemostasisGO:0007599
Protein secretionGO:0009306
Response to external stimulusGO:0009605
Response to biotic stimulusGO:0009607
Response to woundingGO:0009611CCL2 CTSB
Response to bacteriumGO:0009617CCL2
Response to organic substanceGO:0010033
Positive regulation of phosphorus metabolic processGO:0010562
Immunoglobulin mediated immune responseGO:0016064CD74 FCER1G
Leukotriene biosynthetic processGO:0019370ALOX5 ALOX5AP SYK
B cell mediated immunityGO:0019724
Antigen processing and presentationGO:0019882
Antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:0019886CD74 FCER1G
Platelet activationGO:0030168FCER1G LCP2 LYN SERPING1 SRGN SYK
Neutrophil chemotaxisGO:0030593AMICA1 CCL2 FCER1G S100A8 SYK
Leukocyte chemotaxisGO:0030595
Regulation of defense responseGO:0031347
Lipopolysaccharide-mediated signaling pathwayGO:0031663CCL2 LY96 LYN TLR2
Regulation of response to external stimulusGO:0032101
Positive regulation of response to external stimulusGO:0032103
Detection of molecule of bacterial originGO:0032490
Response to lipopolysaccharideGO:0032496IL10RA LY96 S100A8
Interleukin-6 productionGO:0032635
Regulation of interleukin-6 productionGO:0032675
Positive regulation of interleukin-6 productionGO:0032755FCER1G LILRB2 TLR2
Regulation of homeostatic processGO:0032844
Mononuclear cell proliferationGO:0032943
Regulation of mononuclear cell proliferationGO:0032944
Positive regulation of mononuclear cell proliferationGO:0032946
Regulation of mast cell activationGO:0033003LYN
Positive regulation of mast cell activationGO:0033005
Regulation of mast cell activation involved in immune responseGO:0033006
Positive regulation of mast cell activation involved in immune responseGO:0033008
Unsaturated fatty acid metabolic processGO:0033559
Response to cytokine stimulusGO:0034097
Regulation of homotypic cell-cell adhesionGO:0034110
Toll-like receptor 2 signaling pathwayGO:0034134LY96 TLR2
Toll-like receptor 4 signaling pathwayGO:0034142LY96 TLR2
Wound healingGO:0042060S100A8
Positive regulation of t cell proliferationGO:0042102AIF1 LILRB2
T cell activationGO:0042110
Macrophage activationGO:0042116
Response to chemical stimulusGO:0042221
Positive regulation of phosphorylationGO:0042327
TaxisGO:0042330
Leukocyte degranulationGO:0043299
Regulation of leukocyte degranulationGO:0043300
Positive regulation of leukocyte degranulationGO:0043302
Mast cell degranulationGO:0043303
Regulation of mast cell degranulationGO:0043304LYN
Positive regulation of mast cell degranulationGO:0043306FCER1G SYK
Cellular alkene metabolic processGO:0043449
Alkene biosynthetic processGO:0043450
Regulated secretory pathwayGO:0045055
T cell selectionGO:0045058CD74
Innate immune responseGO:0045087C1QB C1S CLEC4A CTSB CYBB FCER1G LCP2 LY96 LYN PSTPIP1 S100A8 SERPING1 SYK TLR2
Regulation of innate immune responseGO:0045088
Leukocyte activationGO:0045321
Mast cell activationGO:0045576FCER1G LCP2
Regulation of t cell differentiationGO:0045580
Positive regulation of t cell differentiationGO:0045582CD74
Positive regulation of lymphocyte differentiationGO:0045621
Positive regulation of phosphate metabolic processGO:0045937
Icosanoid biosynthetic processGO:0046456
Lymphocyte activationGO:0046649
Lymphocyte proliferationGO:0046651
SecretionGO:0046903
Positive regulation of biological processGO:0048518
Regulation of response to stimulusGO:0048583
Positive regulation of response to stimulusGO:0048584
Homeostasis of number of cellsGO:0048872
Cytokine secretionGO:0050663LCP2 LYN
Regulation of lymphocyte proliferationGO:0050670
Positive regulation of lymphocyte proliferationGO:0050671
Regulation of immune responseGO:0050776AMICA1 FCGR2B LILRB2
Positive regulation of immune responseGO:0050778
Regulation of behaviorGO:0050795
CoagulationGO:0050817
Regulation of t cell activationGO:0050863
Regulation of cell activationGO:0050865
Positive regulation of cell activationGO:0050867
Positive regulation of t cell activationGO:0050870CCL2
Regulation of body fluid levelsGO:0050878
Response to stimulusGO:0050896
Leukocyte migrationGO:0050900AMICA1 CD74 FCER1G LYN
Regulation of chemotaxisGO:0050920
Positive regulation of chemotaxisGO:0050921
Regulation of multicellular organismal processGO:0051239
Positive regulation of multicellular organismal processGO:0051240
Regulation of lymphocyte activationGO:0051249
Positive regulation of lymphocyte activationGO:0051251
Multi-organism processGO:0051704
Response to other organismGO:0051707
Nitric-oxide synthase biosynthetic processGO:0051767
Regulation of nitric-oxide synthase biosynthetic processGO:0051769
Positive regulation of nitric-oxide synthase biosynthetic processGO:0051770CCL2 TLR2
Cell chemotaxisGO:0060326
Positive regulation of myeloid leukocyte cytokine production involved in immune responseGO:0061081
Erk1 and erk2 cascadeGO:0070371
Regulation of erk1 and erk2 cascadeGO:0070372LYN SYK
Platelet aggregationGO:0070527
Leukocyte proliferationGO:0070661
Regulation of leukocyte proliferationGO:0070663
Positive regulation of leukocyte proliferationGO:0070665
Cellular response to chemical stimulusGO:0070887
Cellular response to biotic stimulusGO:0071216
Cellular response to molecule of bacterial originGO:0071219
Cellular response to lipopolysaccharideGO:0071222CCL2 LILRB2
Protein activation cascadeGO:0072376
T cell migrationGO:0072678
Regulation of response to stressGO:0080134
Regulation of monocyte chemotaxisGO:0090025LYN
Regulation of platelet aggregationGO:0090330LYN SYK
Dendritic cell differentiationGO:0097028LYN

Enriched Hallmarks of Cancer

Enriched Hallmarks
  • Tumor promoting inflammation Tumor promoting inflammation
  • Tissue invasion and metastasis Tissue invasion and metastasis
  • Evading immune detection Evading immune detection
Legend:
 
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011