TFBS_DB_507

Bicluster Network Summary

Legend:
= Somatically mutated gene/pathway
= TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer

Summary

Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype.
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment.
GenesPatient TumorsFPC Var. Exp.
(Perm. p-value)
Survival
(p-value)
Independent Replication
36392
0.39 (0.0E+00)
3.70 (2.1E-04)
Co-expression
Survival
RegulatorsCausal FlowsEnriched GO BPsEnriched
Hallmarks of Cancer
1600

Replication in independent datasets

StudyFPC Var. Exp. (Perm. p-value)Survival (p-value)
Gravendeel, et al. 2009
0.35 (0.0E+00)
2.93 (3.4E-03)
Madhavan, et al. 2009
0.42 (1.0E-03)
5.63 (1.8E-08)
Murat, et al. 2008
0.33 (1.0E-03)
0.39 (7.0E-01)

Patients

  • TCGA.02.0001
  • TCGA.02.0003
  • TCGA.02.0004
  • TCGA.02.0006
  • TCGA.02.0007
  • TCGA.02.0009
  • TCGA.02.0010
  • TCGA.02.0011
  • TCGA.02.0014
  • TCGA.02.0015
  • TCGA.02.0016
  • TCGA.02.0021
  • TCGA.02.0023
  • TCGA.02.0024
  • TCGA.02.0025
  • TCGA.02.0026
  • TCGA.02.0027
  • TCGA.02.0033
  • TCGA.02.0034
  • TCGA.02.0037
  • TCGA.02.0038
  • TCGA.02.0039
  • TCGA.02.0043
  • TCGA.02.0046
  • TCGA.02.0047
  • TCGA.02.0048
  • TCGA.02.0052
  • TCGA.02.0054
  • TCGA.02.0055
  • TCGA.02.0057
  • TCGA.02.0058
  • TCGA.02.0059
  • TCGA.02.0060
  • TCGA.02.0064
  • TCGA.02.0068
  • TCGA.02.0069
  • TCGA.02.0070
  • TCGA.02.0071
  • TCGA.02.0074
  • TCGA.02.0075
  • TCGA.02.0080
  • TCGA.02.0083
  • TCGA.02.0085
  • TCGA.02.0086
  • TCGA.02.0089
  • TCGA.02.0099
  • TCGA.02.0102
  • TCGA.02.0104
  • TCGA.02.0107
  • TCGA.02.0113
  • TCGA.02.0114
  • TCGA.02.0115
  • TCGA.02.0116
  • TCGA.02.0289
  • TCGA.02.0321
  • TCGA.02.0330
  • TCGA.02.0332
  • TCGA.02.0337
  • TCGA.02.0422
  • TCGA.02.0430
  • TCGA.02.0432
  • TCGA.02.0440
  • TCGA.02.0446
  • TCGA.02.2466
  • TCGA.02.2470
  • TCGA.02.2483
  • TCGA.02.2485
  • TCGA.02.2486
  • TCGA.06.0122
  • TCGA.06.0124
  • TCGA.06.0125
  • TCGA.06.0126
  • TCGA.06.0128
  • TCGA.06.0129
  • TCGA.06.0132
  • TCGA.06.0133
  • TCGA.06.0137
  • TCGA.06.0138
  • TCGA.06.0139
  • TCGA.06.0140
  • TCGA.06.0141
  • TCGA.06.0142
  • TCGA.06.0143
  • TCGA.06.0145
  • TCGA.06.0146
  • TCGA.06.0148
  • TCGA.06.0150
  • TCGA.06.0151
  • TCGA.06.0152
  • TCGA.06.0154
  • TCGA.06.0155
  • TCGA.06.0156
  • TCGA.06.0157
  • TCGA.06.0158
  • TCGA.06.0159
  • TCGA.06.0160
  • TCGA.06.0165
  • TCGA.06.0166
  • TCGA.06.0167
  • TCGA.06.0168
  • TCGA.06.0169
  • TCGA.06.0171
  • TCGA.06.0173
  • TCGA.06.0174
  • TCGA.06.0176
  • TCGA.06.0178
  • TCGA.06.0184
  • TCGA.06.0185
  • TCGA.06.0187
  • TCGA.06.0188
  • TCGA.06.0189
  • TCGA.06.0190
  • TCGA.06.0192
  • TCGA.06.0195
  • TCGA.06.0197
  • TCGA.06.0201
  • TCGA.06.0206
  • TCGA.06.0208
  • TCGA.06.0211
  • TCGA.06.0213
  • TCGA.06.0214
  • TCGA.06.0216
  • TCGA.06.0219
  • TCGA.06.0221
  • TCGA.06.0237
  • TCGA.06.0238
  • TCGA.06.0240
  • TCGA.06.0241
  • TCGA.06.0394
  • TCGA.06.0409
  • TCGA.06.0644
  • TCGA.06.0650
  • TCGA.06.0673
  • TCGA.06.0675
  • TCGA.06.0676
  • TCGA.06.0678
  • TCGA.06.0681
  • TCGA.06.0686
  • TCGA.06.0743
  • TCGA.06.0744
  • TCGA.06.0745
  • TCGA.06.0747
  • TCGA.06.0749
  • TCGA.06.0750
  • TCGA.06.0875
  • TCGA.06.0876
  • TCGA.06.0877
  • TCGA.06.0878
  • TCGA.06.0879
  • TCGA.06.0881
  • TCGA.06.0882
  • TCGA.06.1800
  • TCGA.06.1801
  • TCGA.06.1802
  • TCGA.06.1804
  • TCGA.06.1805
  • TCGA.06.2557
  • TCGA.06.2558
  • TCGA.06.2559
  • TCGA.06.2561
  • TCGA.06.2562
  • TCGA.06.2563
  • TCGA.06.2564
  • TCGA.06.2565
  • TCGA.06.2566
  • TCGA.06.2567
  • TCGA.06.2570
  • TCGA.06.5412
  • TCGA.06.5414
  • TCGA.06.5415
  • TCGA.06.5417
  • TCGA.06.5418
  • TCGA.06.5856
  • TCGA.06.5859
  • TCGA.06.6388
  • TCGA.06.6695
  • TCGA.06.6698
  • TCGA.06.6699
  • TCGA.08.0244
  • TCGA.08.0245
  • TCGA.08.0246
  • TCGA.08.0344
  • TCGA.08.0346
  • TCGA.08.0347
  • TCGA.08.0348
  • TCGA.08.0350
  • TCGA.08.0351
  • TCGA.08.0353
  • TCGA.08.0354
  • TCGA.08.0355
  • TCGA.08.0356
  • TCGA.08.0357
  • TCGA.08.0359
  • TCGA.08.0360
  • TCGA.08.0380
  • TCGA.08.0385
  • TCGA.08.0389
  • TCGA.08.0390
  • TCGA.08.0392
  • TCGA.08.0512
  • TCGA.08.0524
  • TCGA.08.0623
  • TCGA.08.0625
  • TCGA.08.0626
  • TCGA.08.0627
  • TCGA.12.0616
  • TCGA.12.0618
  • TCGA.12.0619
  • TCGA.12.0620
  • TCGA.12.0653
  • TCGA.12.0654
  • TCGA.12.0656
  • TCGA.12.0657
  • TCGA.12.0662
  • TCGA.12.0670
  • TCGA.12.0688
  • TCGA.12.0691
  • TCGA.12.0692
  • TCGA.12.0703
  • TCGA.12.0707
  • TCGA.12.0769
  • TCGA.12.0772
  • TCGA.12.0775
  • TCGA.12.0776
  • TCGA.12.0778
  • TCGA.12.0780
  • TCGA.12.0818
  • TCGA.12.0819
  • TCGA.12.0820
  • TCGA.12.0821
  • TCGA.12.0822
  • TCGA.12.0826
  • TCGA.12.0827
  • TCGA.12.0828
  • TCGA.12.0829
  • TCGA.12.1088
  • TCGA.12.1089
  • TCGA.12.1091
  • TCGA.12.1092
  • TCGA.12.1093
  • TCGA.12.1094
  • TCGA.12.1095
  • TCGA.12.1097
  • TCGA.12.1098
  • TCGA.12.1099
  • TCGA.12.1599
  • TCGA.12.1600
  • TCGA.12.1602
  • TCGA.12.3646
  • TCGA.12.3649
  • TCGA.12.5295
  • TCGA.14.0736
  • TCGA.14.0781
  • TCGA.14.0783
  • TCGA.14.0787
  • TCGA.14.0789
  • TCGA.14.0790
  • TCGA.14.0812
  • TCGA.14.0813
  • TCGA.14.0817
  • TCGA.14.0865
  • TCGA.14.0867
  • TCGA.14.1034
  • TCGA.14.1037
  • TCGA.14.1043
  • TCGA.14.1396
  • TCGA.14.1401
  • TCGA.14.1402
  • TCGA.14.1450
  • TCGA.14.1451
  • TCGA.14.1452
  • TCGA.14.1453
  • TCGA.14.1454
  • TCGA.14.1456
  • TCGA.14.1458
  • TCGA.14.1459
  • TCGA.14.1827
  • TCGA.14.2554
  • TCGA.14.3476
  • TCGA.14.4157
  • TCGA.15.0742
  • TCGA.15.1446
  • TCGA.15.1447
  • TCGA.15.1449
  • TCGA.16.0846
  • TCGA.16.0848
  • TCGA.16.0849
  • TCGA.16.0850
  • TCGA.16.0861
  • TCGA.16.1045
  • TCGA.16.1047
  • TCGA.16.1055
  • TCGA.16.1056
  • TCGA.16.1060
  • TCGA.16.1062
  • TCGA.16.1063
  • TCGA.19.0955
  • TCGA.19.0957
  • TCGA.19.0960
  • TCGA.19.0963
  • TCGA.19.0964
  • TCGA.19.1387
  • TCGA.19.1390
  • TCGA.19.1790
  • TCGA.19.1791
  • TCGA.19.2619
  • TCGA.19.2625
  • TCGA.19.2629
  • TCGA.19.2631
  • TCGA.19.5947
  • TCGA.19.5951
  • TCGA.19.5953
  • TCGA.19.5954
  • TCGA.19.5955
  • TCGA.19.5956
  • TCGA.19.5959
  • TCGA.26.1438
  • TCGA.26.1439
  • TCGA.26.1440
  • TCGA.26.1442
  • TCGA.26.1443
  • TCGA.26.5134
  • TCGA.26.5135
  • TCGA.26.5136
  • TCGA.26.5139
  • TCGA.26.6173
  • TCGA.27.1833
  • TCGA.27.1836
  • TCGA.27.1837
  • TCGA.27.1838
  • TCGA.27.2518
  • TCGA.27.2519
  • TCGA.27.2521
  • TCGA.27.2523
  • TCGA.27.2526
  • TCGA.27.2527
  • TCGA.27.2528
  • TCGA.28.1745
  • TCGA.28.1746
  • TCGA.28.1747
  • TCGA.28.1751
  • TCGA.28.1753
  • TCGA.28.1755
  • TCGA.28.1756
  • TCGA.28.2506
  • TCGA.28.2509
  • TCGA.28.2510
  • TCGA.28.2513
  • TCGA.28.2514
  • TCGA.28.5208
  • TCGA.28.5209
  • TCGA.28.5213
  • TCGA.28.5214
  • TCGA.28.5220
  • TCGA.28.6450
  • TCGA.32.1970
  • TCGA.32.1973
  • TCGA.32.1976
  • TCGA.32.1986
  • TCGA.32.1991
  • TCGA.32.2491
  • TCGA.32.2494
  • TCGA.32.2495
  • TCGA.32.2615
  • TCGA.32.4209
  • TCGA.32.4210
  • TCGA.32.4211
  • TCGA.32.4719
  • TCGA.41.2572
  • TCGA.41.2573
  • TCGA.41.2575
  • TCGA.41.3393
  • TCGA.41.3915
  • TCGA.41.4097
  • TCGA.41.5651
  • TCGA.74.6573
  • TCGA.74.6575
  • TCGA.74.6578
  • TCGA.76.4925
  • TCGA.76.4927
  • TCGA.76.4932
  • TCGA.76.4934
  • TCGA.76.4935
  • TCGA.76.6191
  • TCGA.76.6282
  • TCGA.76.6286
  • TCGA.76.6657
  • TCGA.76.6660
  • TCGA.76.6661
  • TCGA.76.6664
  • TCGA.81.5911
  • TCGA.87.5896

Regulators

TypeNameActionPrior Knowledge
TFIRF1
Activator
Yes

Causal Flows

MutationRegulatorBicluster
EPHB_FORWARD_SIGNALINGIRF1TFBS_DB_507
ERBB4_SIGNALING_EVENTSIRF1TFBS_DB_507
GMCSF_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_507
IL2_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_507
IL2_SIGNALING_EVENTS_MEDIATED_BY_STAT5IRF1TFBS_DB_507
SIGNALING_EVENTS_REGULATED_BY_RET_TYROSINE_KINASEIRF1TFBS_DB_507

Enriched GO Biological Processes

GO TermGO BP IDGenes

Enriched Hallmarks of Cancer

Enriched Hallmarks
Legend:
 
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011