Searched for:  IRF4

IRF4 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in IRF4 are not predicted modulate anything in gbmSYGNAL.
 

IRF4 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
IRF46
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
IRF4 (Rep.)PITA_5711.16 (2.5E-01)Tissue invasion and metastasis
IRF4 (Rep.)TARGETSCAN_672.61 (9.1E-03)
IRF4 (Rep.)TARGETSCAN_823.60 (3.1E-04)Self sufficiency in growth signalsInsensitivity to antigrowth signals
IRF4 (Rep.)TARGETSCAN_2311.99 (4.7E-02)
IRF4 (Rep.)TARGETSCAN_292-1.08 (2.8E-01)Genome instability and mutation
IRF4 (Rep.)TARGETSCAN_6022.74 (6.1E-03)

Biclusters containing IRF4:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Not in any biclusters.