Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype. |
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment. |
Genes | Patient Tumors | FPC Var. Exp. (Perm. p-value) | Survival (p-value) | Independent Replication |
---|---|---|---|---|
47 | 374 | 0.34 (0.0E+00) |
-1.08 (2.8E-01) | Co-expression |
Regulators | Causal Flows | Enriched GO BPs | Enriched Hallmarks of Cancer |
---|---|---|---|
1 | 1 | 7 | 1 |
Study | FPC Var. Exp. (Perm. p-value) | Survival (p-value) |
---|---|---|
Gravendeel, et al. 2009 | 0.15 (4.8E-01) | -0.88 (3.8E-01) |
Madhavan, et al. 2009 | 0.20 (9.7E-01) | -0.10 (9.2E-01) |
Murat, et al. 2008 | 0.23 (5.0E-03) | 0.00 (1.0E+00) |
Type | Name | Action | Prior Knowledge |
---|---|---|---|
TF | IRF4 | Repressor | No |
Mutation | Regulator | Bicluster | ||
---|---|---|---|---|
MUC17 | IRF4 | TARGETSCAN_292 |
GO Term | GO BP ID | Genes |
Chromatin organization | GO:0006325 | EP300 EPC1 SETD2 |
Organelle organization | GO:0006996 | |
Chromatin modification | GO:0016568 | CHD9 EPC2 JMJD1C |
Positive regulation of transcription from rna polymerase ii promoter | GO:0045944 | EP300 EPC1 KLF12 PPARA PROX1 SETX TCF4 TCF7L2 THRAP3 ZNF292 |
Chromosome organization | GO:0051276 | |
Cellular component organization or biogenesis at cellular level | GO:0071841 | |
Cellular component organization at cellular level | GO:0071842 |
|
Legend: Hanahan and Weinberg, Cell 2011 |