Searched for: NFKB1
NFKB1 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in NFKB1 are not predicted modulate anything in gbmSYGNAL.
NFKB1 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| NFKB1 | 12 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| NFKB1 (Rep.) | PITA_122 | 2.57 (1.0E-02) | |
| NFKB1 (Rep.) | PITA_126 | 2.20 (2.8E-02) | |
| NFKB1 (Rep.) | PITA_262 | 3.22 (1.3E-03) | |
| NFKB1 (Rep.) | PITA_266 | 3.46 (5.4E-04) | |
| NFKB1 (Rep.) | PITA_354 | 2.64 (8.3E-03) | |
| NFKB1 (Rep.) | PITA_534 | 3.31 (9.3E-04) | |
| NFKB1 (Rep.) | PITA_582 | 2.55 (1.1E-02) | |
| NFKB1 (Rep.) | TARGETSCAN_173 | 3.33 (8.8E-04) | |
| NFKB1 (Rep.) | TARGETSCAN_269 | 3.40 (6.8E-04) |   |
| NFKB1 (Rep.) | TARGETSCAN_530 | 3.06 (2.2E-03) |  |
| NFKB1 (Rep.) | TFBS_DB_39 | 2.54 (1.1E-02) | |
| NFKB1 (Rep.) | TFBS_DB_152 | 2.43 (1.5E-02) |
Biclusters containing NFKB1:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| NFKB1 | 6 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_157 | 0.51 (0.0) | 3.08325 (0.002) | |
| PITA_266 | 0.49 (0.0) | 3.45812 (0.00054) | |
| TARGETSCAN_262 | 0.56 (0.0) | 2.90362 (0.0037) | |
| TARGETSCAN_421 | 0.4 (0.0) | 2.94325 (0.0032) | |
| TFBS_DB_118 | 0.43 (0.0) | 3.12239 (0.0018) | |
| TFBS_DB_546 | 0.42 (0.0) | 3.41816 (0.00063) |