Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype. |
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment. |
Genes | Patient Tumors | FPC Var. Exp. (Perm. p-value) | Survival (p-value) | Independent Replication |
---|---|---|---|---|
29 | 405 | 0.51 (0.0E+00) |
3.06 (2.2E-03) |
Co-expression Survival |
Regulators | Causal Flows | Enriched GO BPs | Enriched Hallmarks of Cancer |
---|---|---|---|
2 | 2 | 20 | 1 |
Study | FPC Var. Exp. (Perm. p-value) | Survival (p-value) |
---|---|---|
Gravendeel, et al. 2009 | 0.48 (0.0E+00) | 2.97 (3.0E-03) |
Madhavan, et al. 2009 | 0.55 (0.0E+00) | 5.44 (5.4E-08) |
Murat, et al. 2008 | 0.40 (0.0E+00) | 0.13 (9.0E-01) |
Mutation | Regulator | Bicluster | ||
---|---|---|---|---|
LRP2 | NFKB1 | TARGETSCAN_530 | ||
TPTE2 | ETV6 | TARGETSCAN_530 |
GO Term | GO BP ID | Genes |
Response to hypoxia | GO:0001666 | ADM PLOD2 SOCS3 VEGFA |
Morphogenesis of a branching structure | GO:0001763 | |
Response to molecule of bacterial origin | GO:0002237 | |
Immune system process | GO:0002376 | |
Anti-apoptosis | GO:0006916 | |
Response to stress | GO:0006950 | |
Aging | GO:0007568 | ADM FAS MMP7 SOCS3 |
Response to biotic stimulus | GO:0009607 | |
Response to bacterium | GO:0009617 | |
Response to abiotic stimulus | GO:0009628 | |
Antimicrobial humoral response | GO:0019730 | BCL3 |
Response to lipopolysaccharide | GO:0032496 | ADM FAS NOD2 SOCS3 THBD |
Response to chemical stimulus | GO:0042221 | |
Negative regulation of apoptosis | GO:0043066 | BCL3 FAS SOCS3 VEGFA |
Negative regulation of programmed cell death | GO:0043069 | |
Response to other organism | GO:0051707 | |
Negative regulation of cell death | GO:0060548 | |
Spongiotrophoblast layer development | GO:0060712 | ADM |
Morphogenesis of a branching epithelium | GO:0061138 | |
Response to oxygen levels | GO:0070482 |
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Legend: Hanahan and Weinberg, Cell 2011 |