Searched for:  KLF12

KLF12 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in KLF12 are not predicted modulate anything in gbmSYGNAL.
 

KLF12 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
KLF124
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
KLF12 (Rep.)TARGETSCAN_413-1.46 (1.4E-01)Genome instability and mutation
KLF12 (Rep.)TARGETSCAN_545-2.62 (8.9E-03)
KLF12 (Rep.)TFBS_DB_281-2.06 (3.9E-02)Genome instability and mutation
KLF12 (Rep.)PITA_4822.28 (2.3E-02)

Biclusters containing KLF12:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
KLF124
BiclusterVar. Exp. FPC
(Perm. p-value)		Survival
(p-value)		Hallmark(s)
PITA_3900.39 (0.0)-2.46281 (0.014)
PITA_4250.36 (0.0)-2.75435 (0.0059)Genome instability and mutation
TARGETSCAN_2920.34 (0.0)-1.08431 (0.28)Genome instability and mutation
TFBS_DB_900.39 (0.0)-2.43968 (0.015)