List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:

Hanahan and Weinberg, Cell 2011

Hanahan and Weinberg, Cell 2011

Mutations in TCF4 are not predicted modulate anything in gbmSYGNAL.

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:

Hanahan and Weinberg, Cell 2011

Hanahan and Weinberg, Cell 2011

Regulator | Regulated Biclusters |
---|---|

TCF4 | 5 |

Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |

TCF4 (Rep.) | TFBS_DB_426 | -2.23 (2.6E-02) | |

TCF4 (Rep.) | PITA_378 | 3.76 (1.7E-04) | |

TCF4 (Rep.) | TARGETSCAN_246 | 3.27 (1.1E-03) | |

TCF4 (Rep.) | TARGETSCAN_380 | 4.09 (4.3E-05) | |

TCF4 (Rep.) | TFBS_DB_581 | 3.25 (1.2E-03) |

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:

Hanahan and Weinberg, Cell 2011

Hanahan and Weinberg, Cell 2011

Gene | Biclusters |
---|---|

TCF4 | 6 |

Bicluster | Var. Exp. FPC (Perm. p-value) | Survival ( p-value) | Hallmark(s) |

PITA_390 | 0.39 (0.0) | -2.46281 (0.014) | |

PITA_425 | 0.36 (0.0) | -2.75435 (0.0059) | |

TARGETSCAN_292 | 0.34 (0.0) | -1.08431 (0.28) | |

TARGETSCAN_413 | 0.49 (0.0) | -1.45969 (0.14) | |

TFBS_DB_90 | 0.39 (0.0) | -2.43968 (0.015) | |

TFBS_DB_281 | 0.49 (0.0) | -2.06158 (0.039) |