Searched for:  NF1

NF1 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
MutationCausal FlowsRegulatorsTFsmiRNAsBiclusters
NF11165111
MutationRegulatorBiclusterSurvival (p-value)Hallmark(s)
NF1hsa-mir-139PITA_1262.2 (2.8E-02)
NF1IRF1PITA_2823.7 (2.5E-04)Tumor promoting inflammationSelf sufficiency in growth signalsEvading immune detectionInsensitivity to antigrowth signals
NF1IRF1PITA_4523.3 (8.9E-04)Tumor promoting inflammationEvading immune detection
NF1E2F8PITA_4622.5 (1.4E-02)
NF1TCF3PITA_469-2.5 (1.4E-02)
NF1IRF1TARGETSCAN_123.6 (3.1E-04)Tumor promoting inflammationEvading immune detection
NF1E2F7TARGETSCAN_1423.0 (2.4E-03)
NF1hsa-mir-139TARGETSCAN_4164.1 (4.8E-05)
NF1LEF1TFBS_DB_4902.0 (4.4E-02)
NF1IRF1TFBS_DB_5373.7 (2.6E-04)Tumor promoting inflammationEvading immune detection
NF1TCF3TFBS_DB_763.9 (9.3E-05)

NF1 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Not predicted to regulate anything.
 

Biclusters containing NF1:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Not in any biclusters.