Searched for: HLA-A
HLA-A mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in HLA-A are not predicted modulate anything in gbmSYGNAL.
HLA-A regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Not predicted to regulate anything.
Biclusters containing HLA-A:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| HLA-A | 7 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_282 | 0.63 (0.0) | 3.65928 (0.00025) |     |
| PITA_452 | 0.61 (0.0) | 3.32371 (0.00089) | |
| TARGETSCAN_12 | 0.6 (0.0) | 3.60977 (0.00031) | |
| TARGETSCAN_87 | 0.84 (0.0) | 2.34983 (0.019) | |
| TARGETSCAN_416 | 0.41 (0.0) | 4.06558 (4.8e-05) | |
| TFBS_DB_43 | 0.56 (0.0) | 4.00182 (6.3e-05) | |
| TFBS_DB_537 | 0.61 (0.0) | 3.65325 (0.00026) | |