Searched for: ETV6
ETV6 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in ETV6 are not predicted modulate anything in gbmSYGNAL.
ETV6 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| ETV6 | 7 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| ETV6 (Rep.) | PITA_71 | 1.98 (4.7E-02) | |
| ETV6 (Rep.) | TARGETSCAN_9 | 2.71 (6.7E-03) | |
| ETV6 (Rep.) | TARGETSCAN_328 | 2.96 (3.1E-03) | |
| ETV6 (Rep.) | TARGETSCAN_391 | 3.41 (6.5E-04) | |
| ETV6 (Rep.) | TARGETSCAN_456 | 3.28 (1.0E-03) | |
| ETV6 (Rep.) | TARGETSCAN_484 | 4.35 (1.4E-05) | |
| ETV6 (Rep.) | TARGETSCAN_530 | 3.06 (2.2E-03) |  |
Biclusters containing ETV6:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| ETV6 | 8 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_24 | 0.51 (0.0) | 3.71163 (0.00021) | |
| PITA_115 | 0.55 (0.0) | 3.87422 (0.00011) | |
| TARGETSCAN_60 | 0.54 (0.0) | 3.87843 (0.00011) | |
| TARGETSCAN_171 | 0.44 (0.0) | 2.96956 (0.003) |  |
| TFBS_DB_181 | 0.54 (0.0) | 3.68348 (0.00023) | |
| TFBS_DB_386 | 0.49 (0.0) | 3.80656 (0.00014) | |
| TFBS_DB_523 | 0.39 (0.0) | 3.60914 (0.00031) | |
| TFBS_DB_546 | 0.42 (0.0) | 3.41816 (0.00063) |