Searched for: SMAD9
SMAD9 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in SMAD9 are not predicted modulate anything in gbmSYGNAL.
SMAD9 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| SMAD9 | 3 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| SMAD9 (Rep.) | PITA_317 | -1.42 (1.6E-01) |  |
| SMAD9 (Rep.) | TFBS_DB_203 | -2.03 (4.3E-02) | |
| SMAD9 (Rep.) | TFBS_DB_435 | 1.96 (4.9E-02) |
Biclusters containing SMAD9:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Not in any biclusters.