Searched for:  RELB

RELB mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in RELB are not predicted modulate anything in gbmSYGNAL.
 

RELB regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
RELB3
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
RELB (Rep.)TARGETSCAN_2412.69 (7.2E-03)
RELB (Rep.)TARGETSCAN_3442.92 (3.5E-03)
RELB (Rep.)TFBS_DB_1183.12 (1.8E-03)

Biclusters containing RELB:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
RELB6
BiclusterVar. Exp. FPC
(Perm. p-value)		Survival
(p-value)		Hallmark(s)
PITA_1820.45 (0.0)2.61097 (0.009)
PITA_3690.5 (0.0)2.81776 (0.0048)
TARGETSCAN_2410.48 (0.0)2.68684 (0.0072)
TARGETSCAN_4820.47 (0.0)2.63487 (0.0084)
TFBS_DB_4210.42 (0.0)2.51039 (0.012)
TFBS_DB_4840.43 (0.0)4.01343 (6e-05)Tumor promoting inflammationEvading immune detection