Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype. |
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment. |
Genes | Patient Tumors | FPC Var. Exp. (Perm. p-value) | Survival (p-value) | Independent Replication |
---|---|---|---|---|
44 | 398 | 0.43 (0.0E+00) |
4.01 (6.0E-05) |
Co-expression Survival |
Regulators | Causal Flows | Enriched GO BPs | Enriched Hallmarks of Cancer |
---|---|---|---|
0 | 0 | 19 | 2 |
Study | FPC Var. Exp. (Perm. p-value) | Survival (p-value) |
---|---|---|
Gravendeel, et al. 2009 | 0.43 (0.0E+00) | 3.93 (8.5E-05) |
Madhavan, et al. 2009 | 0.50 (0.0E+00) | 5.34 (9.1E-08) |
Murat, et al. 2008 | 0.38 (0.0E+00) | -0.08 (9.3E-01) |
Type | Name | Action | Prior Knowledge |
---|---|---|---|
Mutation | Regulator | Bicluster |
---|
GO Term | GO BP ID | Genes |
Adaptive immune response | GO:0002250 | LILRB2 |
Immune effector process | GO:0002252 | |
Activation of immune response | GO:0002253 | |
Immune system process | GO:0002376 | |
Humoral immune response mediated by circulating immunoglobulin | GO:0002455 | |
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | GO:0002460 | |
Regulation of immune system process | GO:0002682 | |
Positive regulation of immune system process | GO:0002684 | |
Defense response | GO:0006952 | |
Immune response | GO:0006955 | C1QC FCGR2B HLA-DRA LILRB2 TLR2 |
Complement activation | GO:0006956 | C1QB C1QC C1S |
Complement activation, classical pathway | GO:0006958 | C1QB C1QC C1S SERPING1 |
Humoral immune response | GO:0006959 | CCL2 |
Immunoglobulin mediated immune response | GO:0016064 | |
B cell mediated immunity | GO:0019724 | |
Organ development | GO:0048513 | |
Regulation of immune response | GO:0050776 | FCGR2B LILRB2 |
Positive regulation of immune response | GO:0050778 | TGFB2 |
Protein activation cascade | GO:0072376 |
|
Legend: Hanahan and Weinberg, Cell 2011 |