Searched for: JUNB
JUNB mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in JUNB are not predicted modulate anything in gbmSYGNAL.
JUNB regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| JUNB | 2 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| JUNB (Rep.) | TARGETSCAN_482 | 2.63 (8.4E-03) | |
| JUNB (Rep.) | TFBS_DB_107 | 3.25 (1.2E-03) |
Biclusters containing JUNB:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| JUNB | 7 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_182 | 0.45 (0.0) | 2.61097 (0.009) | |
| PITA_314 | 0.59 (0.0) | 2.36214 (0.018) |   |
| PITA_369 | 0.5 (0.0) | 2.81776 (0.0048) | |
| TARGETSCAN_241 | 0.48 (0.0) | 2.68684 (0.0072) | |
| TARGETSCAN_482 | 0.47 (0.0) | 2.63487 (0.0084) | |
| TFBS_DB_421 | 0.42 (0.0) | 2.51039 (0.012) | |
| TFBS_DB_428 | 0.58 (0.0) | 2.61557 (0.0089) |   |