TFBS_DB_428
Bicluster Network Summary
Legend:
= Somatically mutated gene/pathway = TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer
= Somatically mutated gene/pathway = TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer
Summary
| Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype. |
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment. |
| Genes | Patient Tumors | FPC Var. Exp. (Perm. p-value) | Survival (p-value) | Independent Replication |
|---|---|---|---|---|
| 29 | 401 | 0.58 (0.0E+00) |
2.62 (8.9E-03) |
Co-expression Survival |
| Regulators | Causal Flows | Enriched GO BPs | Enriched Hallmarks of Cancer |
|---|---|---|---|
| 2 | 1 | 74 | 4 |
Replication in independent datasets
| Study | FPC Var. Exp. (Perm. p-value) | Survival (p-value) |
|---|---|---|
| Gravendeel, et al. 2009 | 0.54 (0.0E+00) | 1.98 (4.7E-02) |
| Madhavan, et al. 2009 | 0.50 (0.0E+00) | 3.40 (6.7E-04) |
| Murat, et al. 2008 | 0.43 (0.0E+00) | -1.16 (2.4E-01) |
Genes
Patients
- TCGA.02.0001
- TCGA.02.0003
- TCGA.02.0004
- TCGA.02.0006
- TCGA.02.0007
- TCGA.02.0009
- TCGA.02.0010
- TCGA.02.0011
- TCGA.02.0014
- TCGA.02.0015
- TCGA.02.0016
- TCGA.02.0021
- TCGA.02.0023
- TCGA.02.0024
- TCGA.02.0025
- TCGA.02.0026
- TCGA.02.0027
- TCGA.02.0028
- TCGA.02.0034
- TCGA.02.0037
- TCGA.02.0038
- TCGA.02.0039
- TCGA.02.0043
- TCGA.02.0046
- TCGA.02.0047
- TCGA.02.0048
- TCGA.02.0052
- TCGA.02.0054
- TCGA.02.0055
- TCGA.02.0057
- TCGA.02.0058
- TCGA.02.0059
- TCGA.02.0060
- TCGA.02.0064
- TCGA.02.0068
- TCGA.02.0069
- TCGA.02.0070
- TCGA.02.0071
- TCGA.02.0074
- TCGA.02.0075
- TCGA.02.0079
- TCGA.02.0080
- TCGA.02.0083
- TCGA.02.0085
- TCGA.02.0086
- TCGA.02.0089
- TCGA.02.0099
- TCGA.02.0102
- TCGA.02.0104
- TCGA.02.0107
- TCGA.02.0113
- TCGA.02.0114
- TCGA.02.0115
- TCGA.02.0116
- TCGA.02.0289
- TCGA.02.0330
- TCGA.02.0332
- TCGA.02.0337
- TCGA.02.0422
- TCGA.02.0430
- TCGA.02.0432
- TCGA.02.0440
- TCGA.02.0446
- TCGA.02.2466
- TCGA.02.2470
- TCGA.02.2483
- TCGA.02.2486
- TCGA.06.0122
- TCGA.06.0124
- TCGA.06.0125
- TCGA.06.0126
- TCGA.06.0128
- TCGA.06.0129
- TCGA.06.0130
- TCGA.06.0132
- TCGA.06.0133
- TCGA.06.0137
- TCGA.06.0138
- TCGA.06.0140
- TCGA.06.0142
- TCGA.06.0143
- TCGA.06.0145
- TCGA.06.0146
- TCGA.06.0148
- TCGA.06.0150
- TCGA.06.0151
- TCGA.06.0152
- TCGA.06.0154
- TCGA.06.0155
- TCGA.06.0156
- TCGA.06.0157
- TCGA.06.0158
- TCGA.06.0159
- TCGA.06.0160
- TCGA.06.0165
- TCGA.06.0166
- TCGA.06.0167
- TCGA.06.0168
- TCGA.06.0169
- TCGA.06.0171
- TCGA.06.0173
- TCGA.06.0174
- TCGA.06.0176
- TCGA.06.0178
- TCGA.06.0184
- TCGA.06.0185
- TCGA.06.0187
- TCGA.06.0188
- TCGA.06.0189
- TCGA.06.0190
- TCGA.06.0192
- TCGA.06.0195
- TCGA.06.0197
- TCGA.06.0201
- TCGA.06.0208
- TCGA.06.0209
- TCGA.06.0211
- TCGA.06.0213
- TCGA.06.0214
- TCGA.06.0216
- TCGA.06.0219
- TCGA.06.0221
- TCGA.06.0237
- TCGA.06.0238
- TCGA.06.0240
- TCGA.06.0241
- TCGA.06.0394
- TCGA.06.0409
- TCGA.06.0644
- TCGA.06.0649
- TCGA.06.0650
- TCGA.06.0673
- TCGA.06.0675
- TCGA.06.0676
- TCGA.06.0678
- TCGA.06.0681
- TCGA.06.0686
- TCGA.06.0743
- TCGA.06.0744
- TCGA.06.0745
- TCGA.06.0747
- TCGA.06.0749
- TCGA.06.0750
- TCGA.06.0875
- TCGA.06.0876
- TCGA.06.0877
- TCGA.06.0878
- TCGA.06.0879
- TCGA.06.0881
- TCGA.06.0882
- TCGA.06.1086
- TCGA.06.1087
- TCGA.06.1800
- TCGA.06.1801
- TCGA.06.1802
- TCGA.06.1804
- TCGA.06.1805
- TCGA.06.2557
- TCGA.06.2558
- TCGA.06.2559
- TCGA.06.2561
- TCGA.06.2562
- TCGA.06.2563
- TCGA.06.2564
- TCGA.06.2565
- TCGA.06.2566
- TCGA.06.2567
- TCGA.06.2570
- TCGA.06.5412
- TCGA.06.5414
- TCGA.06.5415
- TCGA.06.5417
- TCGA.06.5418
- TCGA.06.5856
- TCGA.06.5859
- TCGA.06.6388
- TCGA.06.6390
- TCGA.06.6695
- TCGA.06.6697
- TCGA.06.6698
- TCGA.06.6699
- TCGA.06.6701
- TCGA.08.0244
- TCGA.08.0245
- TCGA.08.0246
- TCGA.08.0344
- TCGA.08.0346
- TCGA.08.0347
- TCGA.08.0348
- TCGA.08.0350
- TCGA.08.0351
- TCGA.08.0353
- TCGA.08.0354
- TCGA.08.0355
- TCGA.08.0356
- TCGA.08.0357
- TCGA.08.0359
- TCGA.08.0360
- TCGA.08.0385
- TCGA.08.0389
- TCGA.08.0390
- TCGA.08.0510
- TCGA.08.0512
- TCGA.08.0517
- TCGA.08.0524
- TCGA.08.0623
- TCGA.08.0625
- TCGA.08.0626
- TCGA.08.0627
- TCGA.12.0616
- TCGA.12.0618
- TCGA.12.0619
- TCGA.12.0620
- TCGA.12.0653
- TCGA.12.0654
- TCGA.12.0656
- TCGA.12.0657
- TCGA.12.0662
- TCGA.12.0670
- TCGA.12.0688
- TCGA.12.0691
- TCGA.12.0692
- TCGA.12.0703
- TCGA.12.0707
- TCGA.12.0769
- TCGA.12.0772
- TCGA.12.0773
- TCGA.12.0775
- TCGA.12.0776
- TCGA.12.0778
- TCGA.12.0780
- TCGA.12.0818
- TCGA.12.0819
- TCGA.12.0820
- TCGA.12.0821
- TCGA.12.0822
- TCGA.12.0826
- TCGA.12.0827
- TCGA.12.0828
- TCGA.12.0829
- TCGA.12.1088
- TCGA.12.1089
- TCGA.12.1090
- TCGA.12.1091
- TCGA.12.1092
- TCGA.12.1093
- TCGA.12.1094
- TCGA.12.1095
- TCGA.12.1097
- TCGA.12.1098
- TCGA.12.1099
- TCGA.12.1599
- TCGA.12.1600
- TCGA.12.1602
- TCGA.12.3646
- TCGA.12.3649
- TCGA.12.5295
- TCGA.14.0736
- TCGA.14.0781
- TCGA.14.0783
- TCGA.14.0787
- TCGA.14.0789
- TCGA.14.0790
- TCGA.14.0812
- TCGA.14.0813
- TCGA.14.0817
- TCGA.14.0865
- TCGA.14.0867
- TCGA.14.1034
- TCGA.14.1037
- TCGA.14.1043
- TCGA.14.1396
- TCGA.14.1401
- TCGA.14.1402
- TCGA.14.1450
- TCGA.14.1451
- TCGA.14.1452
- TCGA.14.1453
- TCGA.14.1454
- TCGA.14.1456
- TCGA.14.1458
- TCGA.14.1459
- TCGA.14.1827
- TCGA.14.2554
- TCGA.14.3476
- TCGA.14.4157
- TCGA.15.0742
- TCGA.15.1446
- TCGA.15.1447
- TCGA.15.1449
- TCGA.16.0846
- TCGA.16.0848
- TCGA.16.0849
- TCGA.16.0850
- TCGA.16.0861
- TCGA.16.1045
- TCGA.16.1047
- TCGA.16.1055
- TCGA.16.1056
- TCGA.16.1060
- TCGA.16.1062
- TCGA.16.1063
- TCGA.19.0955
- TCGA.19.0957
- TCGA.19.0960
- TCGA.19.0963
- TCGA.19.0964
- TCGA.19.1387
- TCGA.19.1390
- TCGA.19.1787
- TCGA.19.1790
- TCGA.19.1791
- TCGA.19.2619
- TCGA.19.2629
- TCGA.19.2631
- TCGA.19.5947
- TCGA.19.5951
- TCGA.19.5953
- TCGA.19.5954
- TCGA.19.5955
- TCGA.19.5956
- TCGA.19.5959
- TCGA.26.1438
- TCGA.26.1439
- TCGA.26.1440
- TCGA.26.1442
- TCGA.26.1443
- TCGA.26.5133
- TCGA.26.5134
- TCGA.26.5135
- TCGA.26.5136
- TCGA.26.5139
- TCGA.26.6173
- TCGA.27.1833
- TCGA.27.1836
- TCGA.27.1837
- TCGA.27.1838
- TCGA.27.2518
- TCGA.27.2519
- TCGA.27.2521
- TCGA.27.2523
- TCGA.27.2526
- TCGA.27.2527
- TCGA.27.2528
- TCGA.28.1745
- TCGA.28.1746
- TCGA.28.1747
- TCGA.28.1751
- TCGA.28.1753
- TCGA.28.1755
- TCGA.28.1756
- TCGA.28.2506
- TCGA.28.2509
- TCGA.28.2510
- TCGA.28.2513
- TCGA.28.2514
- TCGA.28.5208
- TCGA.28.5209
- TCGA.28.5214
- TCGA.28.5220
- TCGA.28.6450
- TCGA.32.1970
- TCGA.32.1973
- TCGA.32.1976
- TCGA.32.1986
- TCGA.32.1987
- TCGA.32.1991
- TCGA.32.2491
- TCGA.32.2494
- TCGA.32.2495
- TCGA.32.2615
- TCGA.32.4208
- TCGA.32.4209
- TCGA.32.4210
- TCGA.32.4211
- TCGA.32.4719
- TCGA.41.2572
- TCGA.41.2573
- TCGA.41.2575
- TCGA.41.3393
- TCGA.41.3915
- TCGA.41.4097
- TCGA.41.5651
- TCGA.74.6573
- TCGA.74.6575
- TCGA.74.6578
- TCGA.76.4925
- TCGA.76.4927
- TCGA.76.4932
- TCGA.76.4934
- TCGA.76.4935
- TCGA.76.6191
- TCGA.76.6282
- TCGA.76.6286
- TCGA.76.6657
- TCGA.76.6660
- TCGA.76.6661
- TCGA.76.6664
- TCGA.81.5910
- TCGA.81.5911
- TCGA.87.5896
Regulators
| Type | Name | Action | Prior Knowledge |
|---|---|---|---|
| miRNA | hsa-mir-181d | Repressor | Yes |
| miRNA | hsa-mir-551b | Repressor | Yes |
Causal Flows
| Mutation | Regulator | Bicluster | ||
|---|---|---|---|---|
| TBC1D29 | hsa-mir-181d | TFBS_DB_428 |
Enriched GO Biological Processes
| GO Term | GO BP ID | Genes |
| Cell activation | GO:0001775 | |
| Cytokine production | GO:0001816 | |
| Regulation of cytokine production | GO:0001817 | |
| Activation of innate immune response | GO:0002218 | |
| Pattern recognition receptor signaling pathway | GO:0002221 | CLEC7A |
| Response to molecule of bacterial origin | GO:0002237 | IL10 |
| Activation of immune response | GO:0002253 | |
| Immune system process | GO:0002376 | |
| Immune system development | GO:0002520 | |
| Regulation of immune system process | GO:0002682 | |
| Negative regulation of immune system process | GO:0002683 | |
| Positive regulation of immune system process | GO:0002684 | |
| Myd88-dependent toll-like receptor signaling pathway | GO:0002755 | FOS LY96 TLR2 TLR8 |
| Innate immune response-activating signal transduction | GO:0002758 | |
| Immune response-regulating signaling pathway | GO:0002764 | |
| Response to stress | GO:0006950 | |
| Defense response | GO:0006952 | |
| Inflammatory response | GO:0006954 | C5AR1 CCL18 CLEC7A FOS IL10 IL2RA LY96 TLR2 TLR8 |
| Immune response | GO:0006955 | C5AR1 CCL18 IL2RA LILRB2 OSM TLR2 |
| Cellular defense response | GO:0006968 | C5AR1 LILRB2 LY96 |
| Signal transduction | GO:0007165 | C5AR1 CCL18 LILRB2 TLR2 |
| Intracellular protein kinase cascade | GO:0007243 | |
| Detection of biotic stimulus | GO:0009595 | |
| Response to external stimulus | GO:0009605 | |
| Response to biotic stimulus | GO:0009607 | CCL18 |
| Response to wounding | GO:0009611 | CTSB |
| Response to mechanical stimulus | GO:0009612 | JUNB |
| Response to bacterium | GO:0009617 | |
| Response to organic substance | GO:0010033 | |
| Hemopoiesis | GO:0030097 | IL10 |
| Regulation of defense response | GO:0031347 | |
| Negative regulation of defense response | GO:0031348 | |
| Positive regulation of defense response | GO:0031349 | |
| Response to corticosteroid stimulus | GO:0031960 | |
| Regulation of response to external stimulus | GO:0032101 | |
| Regulation of type i interferon production | GO:0032479 | |
| Detection of molecule of bacterial origin | GO:0032490 | |
| Response to lipopolysaccharide | GO:0032496 | C5AR1 FOS IL10RA JUNB LY96 |
| Type i interferon production | GO:0032606 | |
| Tumor necrosis factor production | GO:0032640 | |
| Regulation of interleukin-6 production | GO:0032675 | |
| Regulation of tumor necrosis factor production | GO:0032680 | ZFP36 |
| Negative regulation of mononuclear cell proliferation | GO:0032945 | |
| Toll-like receptor 1 signaling pathway | GO:0034130 | |
| Toll-like receptor 2 signaling pathway | GO:0034134 | FOS LY96 TLR2 |
| Negative regulation of t cell proliferation | GO:0042130 | IL10 IL2RA LILRB2 |
| Innate immune response | GO:0045087 | CLEC4A CLEC7A CTSB FOS IL2RA LY96 TLR2 TLR8 |
| Regulation of innate immune response | GO:0045088 | |
| Positive regulation of innate immune response | GO:0045089 | TLR8 |
| Interferon-alpha biosynthetic process | GO:0045349 | |
| Regulation of interferon-alpha biosynthetic process | GO:0045354 | |
| Positive regulation of biological process | GO:0048518 | |
| Hemopoietic or lymphoid organ development | GO:0048534 | |
| Regulation of response to stimulus | GO:0048583 | |
| Negative regulation of lymphocyte proliferation | GO:0050672 | |
| Regulation of inflammatory response | GO:0050727 | |
| Negative regulation of inflammatory response | GO:0050728 | IL2RA |
| Regulation of immune response | GO:0050776 | LILRB2 |
| Negative regulation of immune response | GO:0050777 | IL2RA LILRB2 |
| Positive regulation of immune response | GO:0050778 | |
| Regulation of biological process | GO:0050789 | |
| Negative regulation of t cell activation | GO:0050868 | |
| Response to stimulus | GO:0050896 | |
| Response to glucocorticoid stimulus | GO:0051384 | DUSP1 IL10 |
| Multi-organism process | GO:0051704 | |
| Response to other organism | GO:0051707 | |
| Cellular response to stimulus | GO:0051716 | |
| Biological regulation | GO:0065007 | |
| Negative regulation of leukocyte proliferation | GO:0070664 | |
| Cellular response to biotic stimulus | GO:0071216 | |
| Cellular response to molecule of bacterial origin | GO:0071219 | |
| Cellular response to lipopolysaccharide | GO:0071222 | IL10 LILRB2 |
| Tumor necrosis factor superfamily cytokine production | GO:0071706 | |
| Regulation of response to stress | GO:0080134 |
Enriched Hallmarks of Cancer
|
Legend: Hanahan and Weinberg, Cell 2011 |
Tumor promoting inflammation
Self sufficiency in growth signals
Evading immune detection
Insensitivity to antigrowth signals