Searched for:  CREB5

CREB5 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in CREB5 are not predicted modulate anything in gbmSYGNAL.
 

CREB5 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
CREB51
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
CREB5 (Rep.)PITA_317-1.42 (1.6E-01)Genome instability and mutation

Biclusters containing CREB5:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
CREB52
BiclusterVar. Exp. FPC
(Perm. p-value)		Survival
(p-value)		Hallmark(s)
TARGETSCAN_5650.32 (0.0)2.36808 (0.018)
TFBS_DB_6030.31 (0.0)3.19531 (0.0014)