Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype. |
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment. |
Genes | Patient Tumors | FPC Var. Exp. (Perm. p-value) | Survival (p-value) | Independent Replication |
---|---|---|---|---|
53 | 375 | 0.39 (0.0E+00) |
2.51 (1.2E-02) |
Co-expression Survival |
Regulators | Causal Flows | Enriched GO BPs | Enriched Hallmarks of Cancer |
---|---|---|---|
1 | 1 | 8 | 0 |
Study | FPC Var. Exp. (Perm. p-value) | Survival (p-value) |
---|---|---|
Gravendeel, et al. 2009 | 0.36 (0.0E+00) | 1.89 (5.8E-02) |
Madhavan, et al. 2009 | 0.41 (7.0E-03) | 3.38 (7.1E-04) |
Murat, et al. 2008 | 0.41 (0.0E+00) | -1.69 (9.1E-02) |
Type | Name | Action | Prior Knowledge |
---|---|---|---|
miRNA | hsa-mir-181d | Repressor | Yes |
Mutation | Regulator | Bicluster | ||
---|---|---|---|---|
TBC1D29 | hsa-mir-181d | TFBS_DB_51 |
GO Term | GO BP ID | Genes |
Immune effector process | GO:0002252 | |
Immune system process | GO:0002376 | |
Response to stress | GO:0006950 | |
Defense response | GO:0006952 | HCP5 |
Immune response | GO:0006955 | C5AR1 CCL22 CD86 CXCL13 GZMH IGKV1-5 IL18RAP PPBP |
Response to biotic stimulus | GO:0009607 | |
Defense response to bacterium | GO:0042742 | CLEC4E CXCL13 IL10 LALBA PPBP S100A12 |
Response to other organism | GO:0051707 |
|
Legend: Hanahan and Weinberg, Cell 2011 |