Searched for: ZIC5
ZIC5 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in ZIC5 are not predicted modulate anything in gbmSYGNAL.
ZIC5 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| ZIC5 | 9 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| ZIC5 (Rep.) | PITA_141 | 4.69 (2.7E-06) | |
| ZIC5 (Rep.) | PITA_589 | 2.73 (6.3E-03) | |
| ZIC5 (Rep.) | PITA_591 | 4.91 (9.3E-07) | |
| ZIC5 (Rep.) | TARGETSCAN_502 | 3.69 (2.2E-04) | |
| ZIC5 (Rep.) | TARGETSCAN_602 | 2.74 (6.1E-03) | |
| ZIC5 (Rep.) | TFBS_DB_95 | 3.71 (2.0E-04) | |
| ZIC5 (Rep.) | TFBS_DB_113 | 4.11 (4.0E-05) | |
| ZIC5 (Rep.) | TFBS_DB_266 | 3.12 (1.8E-03) | |
| ZIC5 (Rep.) | TFBS_DB_293 | 2.63 (8.6E-03) |
Biclusters containing ZIC5:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Not in any biclusters.