Searched for:  ZHX3

ZHX3 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in ZHX3 are not predicted modulate anything in gbmSYGNAL.
 

ZHX3 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
ZHX33
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
ZHX3 (Rep.)TARGETSCAN_1402.55 (1.1E-02)
ZHX3 (Rep.)TFBS_DB_1822.78 (5.5E-03)
ZHX3 (Rep.)TFBS_DB_2122.71 (6.8E-03)

Biclusters containing ZHX3:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
ZHX34
BiclusterVar. Exp. FPC
(Perm. p-value)		Survival
(p-value)		Hallmark(s)
PITA_480.39 (0.0)2.68682 (0.0072)
TARGETSCAN_6020.46 (0.0)2.74223 (0.0061)
TFBS_DB_910.38 (0.0)2.78979 (0.0053)Sustained angiogenesis
TFBS_DB_2120.37 (0.0)2.70796 (0.0068)