Searched for:  TFCP2L1

TFCP2L1 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in TFCP2L1 are not predicted modulate anything in gbmSYGNAL.
 

TFCP2L1 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
TFCP2L15
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
TFCP2L1 (Rep.)PITA_5454.15 (3.3E-05)
TFCP2L1 (Rep.)TARGETSCAN_104.47 (7.7E-06)
TFCP2L1 (Rep.)TARGETSCAN_2233.39 (7.0E-04)
TFCP2L1 (Rep.)TFBS_DB_4351.96 (4.9E-02)
TFCP2L1 (Rep.)TFBS_DB_4802.01 (4.4E-02)

Biclusters containing TFCP2L1:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
TFCP2L15
BiclusterVar. Exp. FPC
(Perm. p-value)		Survival
(p-value)		Hallmark(s)
PITA_2150.35 (0.0)3.42472 (0.00062)
PITA_5450.36 (0.0)4.14982 (3.3e-05)
TARGETSCAN_1420.34 (0.0)3.0376 (0.0024)
TARGETSCAN_4010.39 (0.0)3.51746 (0.00044)
TFBS_DB_1980.4 (0.0)4.16041 (3.2e-05)