Searched for:  SOX9

SOX9 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in SOX9 are not predicted modulate anything in gbmSYGNAL.
 

SOX9 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
SOX92
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
SOX9 (Rep.)PITA_1453.88 (1.0E-04)
SOX9 (Rep.)TARGETSCAN_4293.10 (1.9E-03)

Biclusters containing SOX9:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
SOX96
BiclusterVar. Exp. FPC
(Perm. p-value)		Survival
(p-value)		Hallmark(s)
PITA_1630.35 (0.0)2.5627 (0.01)
TARGETSCAN_1830.38 (0.0)3.31482 (0.00092)
TARGETSCAN_5650.32 (0.0)2.36808 (0.018)
TFBS_DB_1310.38 (0.0)3.64246 (0.00027)
TFBS_DB_3170.32 (0.0)3.61617 (0.0003)
TFBS_DB_6030.31 (0.0)3.19531 (0.0014)