Searched for: RARA
RARA mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in RARA are not predicted modulate anything in gbmSYGNAL.
RARA regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| RARA | 4 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| RARA (Rep.) | PITA_337 | 2.52 (1.2E-02) | |
| RARA (Rep.) | PITA_589 | 2.73 (6.3E-03) | |
| RARA (Rep.) | TARGETSCAN_356 | 3.31 (9.4E-04) | |
| RARA (Rep.) | TFBS_DB_95 | 3.71 (2.0E-04) |
Biclusters containing RARA:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| RARA | 2 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| TARGETSCAN_496 | 0.34 (0.0) | 2.81105 (0.0049) | |
| TFBS_DB_269 | 0.33 (0.0) | 3.80677 (0.00014) |