Searched for: ETV7
ETV7 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in ETV7 are not predicted modulate anything in gbmSYGNAL.
ETV7 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| ETV7 | 13 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| ETV7 (Rep.) | PITA_135 | 2.72 (6.5E-03) | |
| ETV7 (Rep.) | PITA_229 | 2.48 (1.3E-02) | |
| ETV7 (Rep.) | PITA_591 | 4.91 (9.3E-07) | |
| ETV7 (Rep.) | TARGETSCAN_60 | 3.88 (1.1E-04) | |
| ETV7 (Rep.) | TARGETSCAN_118 | 2.57 (1.0E-02) | |
| ETV7 (Rep.) | TARGETSCAN_231 | 1.99 (4.7E-02) | |
| ETV7 (Rep.) | TARGETSCAN_391 | 3.41 (6.5E-04) | |
| ETV7 (Rep.) | TARGETSCAN_592 | 3.17 (1.5E-03) | |
| ETV7 (Rep.) | TFBS_DB_115 | 3.34 (8.5E-04) | |
| ETV7 (Rep.) | TFBS_DB_181 | 3.68 (2.3E-04) | |
| ETV7 (Rep.) | TFBS_DB_253 | 2.33 (2.0E-02) | |
| ETV7 (Rep.) | TFBS_DB_529 | 3.24 (1.2E-03) | |
| ETV7 (Rep.) | TFBS_DB_574 | 2.58 (9.7E-03) |
Biclusters containing ETV7:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| ETV7 | 6 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_71 | 0.51 (0.0) | 1.98486 (0.047) | |
| PITA_100 | 0.49 (0.0) | 2.87383 (0.0041) | |
| TARGETSCAN_9 | 0.47 (0.0) | 2.71298 (0.0067) | |
| TARGETSCAN_288 | 0.48 (0.0) | 3.88942 (0.0001) | |
| TFBS_DB_71 | 0.5 (0.0) | 3.15742 (0.0016) | |
| TFBS_DB_213 | 0.39 (0.0) | 3.20359 (0.0014) |