Searched for: EGR3
EGR3 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in EGR3 are not predicted modulate anything in gbmSYGNAL.
EGR3 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| EGR3 | 1 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| EGR3 (Rep.) | TFBS_DB_239 | 1.55 (1.2E-01) |   |
Biclusters containing EGR3:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| EGR3 | 5 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_358 | 0.35 (0.0) | 3.86117 (0.00011) | |
| TARGETSCAN_277 | 0.36 (0.0) | 3.2263 (0.0013) | |
| TARGETSCAN_584 | 0.33 (0.0) | 4.30648 (1.7e-05) | |
| TFBS_DB_202 | 0.33 (0.0) | 2.12722 (0.033) | |
| TFBS_DB_287 | 0.32 (0.0) | -3.17044 (0.0015) |