Searched for: E2F4
E2F4 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in E2F4 are not predicted modulate anything in gbmSYGNAL.
E2F4 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| E2F4 | 4 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| E2F4 (Rep.) | PITA_160 | 4.12 (3.8E-05) | |
| E2F4 (Rep.) | PITA_320 | 3.25 (1.1E-03) | |
| E2F4 (Rep.) | TFBS_DB_263 | 3.62 (3.0E-04) | |
| E2F4 (Rep.) | TFBS_DB_294 | 2.71 (6.6E-03) |
Biclusters containing E2F4:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Not in any biclusters.