Searched for: CREB1
CREB1 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in CREB1 are not predicted modulate anything in gbmSYGNAL.
CREB1 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| CREB1 | 2 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| CREB1 (Rep.) | TFBS_DB_263 | 3.62 (3.0E-04) | |
| CREB1 (Rep.) | TFBS_DB_42 | 3.43 (6.0E-04) |
Biclusters containing CREB1:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| CREB1 | 2 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_564 | 0.37 (0.0) | 2.69373 (0.0071) | |
| TFBS_DB_49 | 0.33 (0.0) | 1.97553 (0.048) |