List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:

Hanahan and Weinberg, Cell 2011

Hanahan and Weinberg, Cell 2011

Mutations in hsa-mir-181a-3p are not predicted modulate anything in gbmSYGNAL.

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:

Hanahan and Weinberg, Cell 2011

Hanahan and Weinberg, Cell 2011

Regulator | Regulated Biclusters |
---|---|

hsa-mir-181a-3p | 1 |

Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |

hsa-mir-181a-3p (Rep.) | PITA_438 | 3.48 (5.0E-04) |

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:

Hanahan and Weinberg, Cell 2011

Hanahan and Weinberg, Cell 2011

Not in any biclusters.