Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype. |
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment. |
Genes | Patient Tumors | FPC Var. Exp. (Perm. p-value) | Survival (p-value) | Independent Replication |
---|---|---|---|---|
23 | 408 | 0.65 (0.0E+00) |
2.55 (1.1E-02) |
Co-expression Survival |
Regulators | Causal Flows | Enriched GO BPs | Enriched Hallmarks of Cancer |
---|---|---|---|
1 | 1 | 13 | 2 |
Study | FPC Var. Exp. (Perm. p-value) | Survival (p-value) |
---|---|---|
Gravendeel, et al. 2009 | 0.57 (0.0E+00) | 2.88 (4.0E-03) |
Madhavan, et al. 2009 | 0.59 (0.0E+00) | 2.27 (2.3E-02) |
Murat, et al. 2008 | 0.54 (0.0E+00) | -1.00 (3.2E-01) |
Type | Name | Action | Prior Knowledge |
---|---|---|---|
TF | ELF1 | Activator | Yes |
Mutation | Regulator | Bicluster | ||
---|---|---|---|---|
REELIN_SIGNALING_PATHWAY | ELF1 | PITA_61 |
GO Term | GO BP ID | Genes |
Activation of immune response | GO:0002253 | |
Immune system process | GO:0002376 | |
Immune response-activating cell surface receptor signaling pathway | GO:0002429 | |
Regulation of immune system process | GO:0002682 | |
Immune response-activating signal transduction | GO:0002757 | |
Immune response-regulating signaling pathway | GO:0002764 | |
Immune response-regulating cell surface receptor signaling pathway | GO:0002768 | LYN |
Response to stress | GO:0006950 | |
Defense response | GO:0006952 | LILRA2 RNASE6 |
Immune response | GO:0006955 | CD86 FCGR1A FCGR3A HLA-DRB5 IL18 |
Innate immune response | GO:0045087 | CD86 FCGR1A FCGR3A LAT2 LY86 LYN PSMB10 |
Regulation of immune response | GO:0050776 | FCGR1A FCGR3A HCST |
Cellular response to interferon-gamma | GO:0071346 |
|
Legend: Hanahan and Weinberg, Cell 2011 |