Searched for: TCF4
TCF4 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in TCF4 are not predicted modulate anything in gbmSYGNAL.
TCF4 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| TCF4 | 5 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| TCF4 (Rep.) | TFBS_DB_426 | -2.23 (2.6E-02) | |
| TCF4 (Rep.) | PITA_378 | 3.76 (1.7E-04) | |
| TCF4 (Rep.) | TARGETSCAN_246 | 3.27 (1.1E-03) | |
| TCF4 (Rep.) | TARGETSCAN_380 | 4.09 (4.3E-05) | |
| TCF4 (Rep.) | TFBS_DB_581 | 3.25 (1.2E-03) |
Biclusters containing TCF4:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| TCF4 | 6 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_390 | 0.39 (0.0) | -2.46281 (0.014) | |
| PITA_425 | 0.36 (0.0) | -2.75435 (0.0059) |  |
| TARGETSCAN_292 | 0.34 (0.0) | -1.08431 (0.28) | |
| TARGETSCAN_413 | 0.49 (0.0) | -1.45969 (0.14) | |
| TFBS_DB_90 | 0.39 (0.0) | -2.43968 (0.015) | |
| TFBS_DB_281 | 0.49 (0.0) | -2.06158 (0.039) | |