Searched for:  TBX1

TBX1 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in TBX1 are not predicted modulate anything in gbmSYGNAL.
 

TBX1 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
TBX113
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
TBX1 (Rep.)PITA_662.83 (4.7E-03)
TBX1 (Rep.)PITA_1352.72 (6.5E-03)
TBX1 (Rep.)PITA_1632.56 (1.0E-02)
TBX1 (Rep.)PITA_3002.73 (6.2E-03)
TBX1 (Rep.)TARGETSCAN_135-1.97 (4.8E-02)
TBX1 (Rep.)TARGETSCAN_3913.41 (6.5E-04)
TBX1 (Rep.)TARGETSCAN_4293.10 (1.9E-03)
TBX1 (Rep.)TFBS_DB_953.71 (2.0E-04)
TBX1 (Rep.)TFBS_DB_1162.52 (1.2E-02)
TBX1 (Rep.)TFBS_DB_2663.12 (1.8E-03)
TBX1 (Rep.)TFBS_DB_2762.71 (6.8E-03)
TBX1 (Rep.)TFBS_DB_5162.61 (9.0E-03)
TBX1 (Rep.)TFBS_DB_6093.23 (1.2E-03)

Biclusters containing TBX1:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Not in any biclusters.