Searched for: ELK3
ELK3 mutations modulate:
List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
Mutations in ELK3 are not predicted modulate anything in gbmSYGNAL.
ELK3 regulates:
List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Regulator | Regulated Biclusters |
|---|---|
| ELK3 | 1 |
| Regulator (Action) | Bicluster | Survival (p-value) | Hallmark(s) |
| ELK3 (Rep.) | TARGETSCAN_484 | 4.35 (1.4E-05) |
Biclusters containing ELK3:
List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hanahan and Weinberg, Cell 2011
Hanahan and Weinberg, Cell 2011
| Gene | Biclusters |
|---|---|
| ELK3 | 5 |
| Bicluster | Var. Exp. FPC (Perm. p-value) | Survival (p-value) | Hallmark(s) |
| PITA_266 | 0.49 (0.0) | 3.45812 (0.00054) | |
| TARGETSCAN_401 | 0.39 (0.0) | 3.51746 (0.00044) | |
| TARGETSCAN_484 | 0.35 (0.0) | 4.34659 (1.4e-05) | |
| TFBS_DB_188 | 0.44 (0.0) | 4.2741 (1.9e-05) | |
| TFBS_DB_490 | 0.43 (0.0) | 2.01415 (0.044) |