TFBS_DB_72

Bicluster Network Summary

Legend:
= Somatically mutated gene/pathway
= TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer

Summary

Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype.
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment.
GenesPatient TumorsFPC Var. Exp.
(Perm. p-value)
Survival
(p-value)
Independent Replication
32400
0.53 (0.0E+00)
3.02 (2.5E-03)
Co-expression
Survival
RegulatorsCausal FlowsEnriched GO BPsEnriched
Hallmarks of Cancer
1050

Replication in independent datasets

StudyFPC Var. Exp. (Perm. p-value)Survival (p-value)
Gravendeel, et al. 2009
0.57 (0.0E+00)
2.13 (3.3E-02)
Madhavan, et al. 2009
0.65 (0.0E+00)
3.07 (2.1E-03)
Murat, et al. 2008
0.51 (0.0E+00)
-1.53 (1.2E-01)

Patients

  • TCGA.02.0001
  • TCGA.02.0003
  • TCGA.02.0004
  • TCGA.02.0006
  • TCGA.02.0007
  • TCGA.02.0009
  • TCGA.02.0010
  • TCGA.02.0011
  • TCGA.02.0014
  • TCGA.02.0015
  • TCGA.02.0016
  • TCGA.02.0021
  • TCGA.02.0023
  • TCGA.02.0024
  • TCGA.02.0025
  • TCGA.02.0026
  • TCGA.02.0027
  • TCGA.02.0028
  • TCGA.02.0033
  • TCGA.02.0034
  • TCGA.02.0037
  • TCGA.02.0038
  • TCGA.02.0039
  • TCGA.02.0043
  • TCGA.02.0046
  • TCGA.02.0047
  • TCGA.02.0048
  • TCGA.02.0051
  • TCGA.02.0052
  • TCGA.02.0054
  • TCGA.02.0055
  • TCGA.02.0057
  • TCGA.02.0058
  • TCGA.02.0059
  • TCGA.02.0060
  • TCGA.02.0068
  • TCGA.02.0069
  • TCGA.02.0070
  • TCGA.02.0071
  • TCGA.02.0074
  • TCGA.02.0075
  • TCGA.02.0079
  • TCGA.02.0080
  • TCGA.02.0083
  • TCGA.02.0085
  • TCGA.02.0086
  • TCGA.02.0089
  • TCGA.02.0099
  • TCGA.02.0102
  • TCGA.02.0104
  • TCGA.02.0107
  • TCGA.02.0113
  • TCGA.02.0114
  • TCGA.02.0115
  • TCGA.02.0116
  • TCGA.02.0289
  • TCGA.02.0321
  • TCGA.02.0330
  • TCGA.02.0332
  • TCGA.02.0337
  • TCGA.02.0422
  • TCGA.02.0430
  • TCGA.02.0432
  • TCGA.02.0440
  • TCGA.02.0446
  • TCGA.02.2466
  • TCGA.02.2483
  • TCGA.02.2485
  • TCGA.02.2486
  • TCGA.06.0122
  • TCGA.06.0124
  • TCGA.06.0125
  • TCGA.06.0126
  • TCGA.06.0128
  • TCGA.06.0129
  • TCGA.06.0132
  • TCGA.06.0133
  • TCGA.06.0137
  • TCGA.06.0138
  • TCGA.06.0140
  • TCGA.06.0141
  • TCGA.06.0142
  • TCGA.06.0143
  • TCGA.06.0145
  • TCGA.06.0146
  • TCGA.06.0148
  • TCGA.06.0150
  • TCGA.06.0151
  • TCGA.06.0152
  • TCGA.06.0154
  • TCGA.06.0155
  • TCGA.06.0156
  • TCGA.06.0157
  • TCGA.06.0158
  • TCGA.06.0159
  • TCGA.06.0160
  • TCGA.06.0165
  • TCGA.06.0166
  • TCGA.06.0167
  • TCGA.06.0168
  • TCGA.06.0171
  • TCGA.06.0173
  • TCGA.06.0174
  • TCGA.06.0176
  • TCGA.06.0178
  • TCGA.06.0184
  • TCGA.06.0185
  • TCGA.06.0187
  • TCGA.06.0188
  • TCGA.06.0189
  • TCGA.06.0190
  • TCGA.06.0192
  • TCGA.06.0195
  • TCGA.06.0197
  • TCGA.06.0201
  • TCGA.06.0206
  • TCGA.06.0208
  • TCGA.06.0209
  • TCGA.06.0211
  • TCGA.06.0213
  • TCGA.06.0214
  • TCGA.06.0216
  • TCGA.06.0219
  • TCGA.06.0221
  • TCGA.06.0237
  • TCGA.06.0238
  • TCGA.06.0240
  • TCGA.06.0241
  • TCGA.06.0394
  • TCGA.06.0409
  • TCGA.06.0644
  • TCGA.06.0649
  • TCGA.06.0650
  • TCGA.06.0673
  • TCGA.06.0675
  • TCGA.06.0676
  • TCGA.06.0678
  • TCGA.06.0681
  • TCGA.06.0686
  • TCGA.06.0743
  • TCGA.06.0744
  • TCGA.06.0745
  • TCGA.06.0747
  • TCGA.06.0749
  • TCGA.06.0750
  • TCGA.06.0875
  • TCGA.06.0876
  • TCGA.06.0877
  • TCGA.06.0878
  • TCGA.06.0879
  • TCGA.06.0881
  • TCGA.06.0882
  • TCGA.06.1084
  • TCGA.06.1086
  • TCGA.06.1087
  • TCGA.06.1800
  • TCGA.06.1801
  • TCGA.06.1802
  • TCGA.06.1804
  • TCGA.06.1805
  • TCGA.06.2557
  • TCGA.06.2558
  • TCGA.06.2559
  • TCGA.06.2561
  • TCGA.06.2562
  • TCGA.06.2563
  • TCGA.06.2564
  • TCGA.06.2565
  • TCGA.06.2566
  • TCGA.06.2567
  • TCGA.06.2569
  • TCGA.06.2570
  • TCGA.06.5412
  • TCGA.06.5414
  • TCGA.06.5415
  • TCGA.06.5417
  • TCGA.06.5418
  • TCGA.06.5856
  • TCGA.06.5859
  • TCGA.06.6388
  • TCGA.06.6695
  • TCGA.06.6698
  • TCGA.06.6699
  • TCGA.08.0244
  • TCGA.08.0245
  • TCGA.08.0246
  • TCGA.08.0344
  • TCGA.08.0346
  • TCGA.08.0347
  • TCGA.08.0348
  • TCGA.08.0350
  • TCGA.08.0351
  • TCGA.08.0353
  • TCGA.08.0354
  • TCGA.08.0355
  • TCGA.08.0356
  • TCGA.08.0357
  • TCGA.08.0359
  • TCGA.08.0360
  • TCGA.08.0380
  • TCGA.08.0385
  • TCGA.08.0389
  • TCGA.08.0390
  • TCGA.08.0392
  • TCGA.08.0512
  • TCGA.08.0517
  • TCGA.08.0524
  • TCGA.08.0623
  • TCGA.08.0625
  • TCGA.08.0626
  • TCGA.08.0627
  • TCGA.12.0616
  • TCGA.12.0618
  • TCGA.12.0619
  • TCGA.12.0620
  • TCGA.12.0653
  • TCGA.12.0654
  • TCGA.12.0656
  • TCGA.12.0657
  • TCGA.12.0662
  • TCGA.12.0670
  • TCGA.12.0688
  • TCGA.12.0691
  • TCGA.12.0692
  • TCGA.12.0703
  • TCGA.12.0707
  • TCGA.12.0769
  • TCGA.12.0772
  • TCGA.12.0773
  • TCGA.12.0775
  • TCGA.12.0776
  • TCGA.12.0778
  • TCGA.12.0780
  • TCGA.12.0818
  • TCGA.12.0819
  • TCGA.12.0820
  • TCGA.12.0821
  • TCGA.12.0822
  • TCGA.12.0826
  • TCGA.12.0827
  • TCGA.12.0828
  • TCGA.12.0829
  • TCGA.12.1088
  • TCGA.12.1089
  • TCGA.12.1090
  • TCGA.12.1091
  • TCGA.12.1092
  • TCGA.12.1093
  • TCGA.12.1094
  • TCGA.12.1095
  • TCGA.12.1097
  • TCGA.12.1098
  • TCGA.12.1099
  • TCGA.12.1599
  • TCGA.12.1600
  • TCGA.12.1602
  • TCGA.12.3646
  • TCGA.12.3649
  • TCGA.14.0736
  • TCGA.14.0781
  • TCGA.14.0783
  • TCGA.14.0789
  • TCGA.14.0790
  • TCGA.14.0812
  • TCGA.14.0813
  • TCGA.14.0817
  • TCGA.14.0865
  • TCGA.14.0867
  • TCGA.14.0871
  • TCGA.14.1034
  • TCGA.14.1037
  • TCGA.14.1043
  • TCGA.14.1396
  • TCGA.14.1401
  • TCGA.14.1402
  • TCGA.14.1450
  • TCGA.14.1451
  • TCGA.14.1452
  • TCGA.14.1453
  • TCGA.14.1454
  • TCGA.14.1456
  • TCGA.14.1458
  • TCGA.14.1459
  • TCGA.14.1827
  • TCGA.14.1829
  • TCGA.14.2554
  • TCGA.14.3476
  • TCGA.14.4157
  • TCGA.15.0742
  • TCGA.15.1446
  • TCGA.15.1447
  • TCGA.15.1449
  • TCGA.16.0846
  • TCGA.16.0848
  • TCGA.16.0849
  • TCGA.16.0850
  • TCGA.16.0861
  • TCGA.16.1045
  • TCGA.16.1047
  • TCGA.16.1055
  • TCGA.16.1056
  • TCGA.16.1060
  • TCGA.16.1062
  • TCGA.16.1063
  • TCGA.19.0955
  • TCGA.19.0957
  • TCGA.19.0960
  • TCGA.19.0963
  • TCGA.19.0964
  • TCGA.19.1387
  • TCGA.19.1390
  • TCGA.19.1392
  • TCGA.19.1787
  • TCGA.19.1790
  • TCGA.19.1791
  • TCGA.19.2625
  • TCGA.19.2629
  • TCGA.19.2631
  • TCGA.19.5947
  • TCGA.19.5951
  • TCGA.19.5953
  • TCGA.19.5954
  • TCGA.19.5955
  • TCGA.19.5956
  • TCGA.19.5959
  • TCGA.26.1438
  • TCGA.26.1439
  • TCGA.26.1440
  • TCGA.26.1442
  • TCGA.26.1443
  • TCGA.26.5133
  • TCGA.26.5134
  • TCGA.26.5135
  • TCGA.26.5136
  • TCGA.26.5139
  • TCGA.26.6173
  • TCGA.27.1833
  • TCGA.27.1836
  • TCGA.27.1837
  • TCGA.27.1838
  • TCGA.27.2518
  • TCGA.27.2519
  • TCGA.27.2521
  • TCGA.27.2523
  • TCGA.27.2527
  • TCGA.27.2528
  • TCGA.28.1745
  • TCGA.28.1746
  • TCGA.28.1747
  • TCGA.28.1751
  • TCGA.28.1753
  • TCGA.28.1756
  • TCGA.28.2506
  • TCGA.28.2509
  • TCGA.28.2510
  • TCGA.28.2513
  • TCGA.28.2514
  • TCGA.28.5208
  • TCGA.28.5209
  • TCGA.28.5213
  • TCGA.28.5214
  • TCGA.28.5220
  • TCGA.28.6450
  • TCGA.32.1970
  • TCGA.32.1973
  • TCGA.32.1986
  • TCGA.32.1987
  • TCGA.32.1991
  • TCGA.32.2491
  • TCGA.32.2494
  • TCGA.32.2495
  • TCGA.32.2615
  • TCGA.32.4208
  • TCGA.32.4209
  • TCGA.32.4210
  • TCGA.32.4211
  • TCGA.32.4719
  • TCGA.41.2572
  • TCGA.41.2573
  • TCGA.41.2575
  • TCGA.41.3915
  • TCGA.41.4097
  • TCGA.41.5651
  • TCGA.74.6573
  • TCGA.74.6575
  • TCGA.74.6578
  • TCGA.76.4925
  • TCGA.76.4927
  • TCGA.76.4932
  • TCGA.76.4934
  • TCGA.76.4935
  • TCGA.76.6191
  • TCGA.76.6282
  • TCGA.76.6286
  • TCGA.76.6657
  • TCGA.76.6660
  • TCGA.76.6661
  • TCGA.76.6664
  • TCGA.81.5911
  • TCGA.87.5896

Regulators

TypeNameActionPrior Knowledge
miRNAhsa-mir-9
Repressor
Yes

Causal Flows

MutationRegulatorBicluster

Enriched GO Biological Processes

GO TermGO BP IDGenes
Response to stressGO:0006950
Defense responseGO:0006952
Inflammatory responseGO:0006954AOAH C3AR1 CCL13 CCL23 CD27 FOLR2 IL18RAP PF4 PPBP PROK2 S100A12
Immune responseGO:0006955CCL23 CD27 CFP IL18RAP PF4 PPBP
Response to woundingGO:0009611

Enriched Hallmarks of Cancer

Enriched Hallmarks
Legend:
 
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011