TFBS_DB_326

Bicluster Network Summary

Legend:
= Somatically mutated gene/pathway
= TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer

Summary

Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype.
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment.
GenesPatient TumorsFPC Var. Exp.
(Perm. p-value)
Survival
(p-value)
Independent Replication
71413
0.55 (0.0E+00)
3.28 (1.0E-03)
Co-expression
Survival
RegulatorsCausal FlowsEnriched GO BPsEnriched
Hallmarks of Cancer
2121022

Replication in independent datasets

StudyFPC Var. Exp. (Perm. p-value)Survival (p-value)
Gravendeel, et al. 2009
0.51 (0.0E+00)
2.63 (8.5E-03)
Madhavan, et al. 2009
0.56 (0.0E+00)
3.38 (7.3E-04)
Murat, et al. 2008
0.44 (0.0E+00)
-1.38 (1.7E-01)

Patients

  • TCGA.02.0001
  • TCGA.02.0003
  • TCGA.02.0004
  • TCGA.02.0006
  • TCGA.02.0007
  • TCGA.02.0009
  • TCGA.02.0010
  • TCGA.02.0011
  • TCGA.02.0014
  • TCGA.02.0015
  • TCGA.02.0016
  • TCGA.02.0021
  • TCGA.02.0023
  • TCGA.02.0024
  • TCGA.02.0025
  • TCGA.02.0026
  • TCGA.02.0027
  • TCGA.02.0028
  • TCGA.02.0033
  • TCGA.02.0034
  • TCGA.02.0037
  • TCGA.02.0038
  • TCGA.02.0039
  • TCGA.02.0043
  • TCGA.02.0046
  • TCGA.02.0047
  • TCGA.02.0048
  • TCGA.02.0051
  • TCGA.02.0052
  • TCGA.02.0054
  • TCGA.02.0055
  • TCGA.02.0057
  • TCGA.02.0058
  • TCGA.02.0059
  • TCGA.02.0060
  • TCGA.02.0064
  • TCGA.02.0068
  • TCGA.02.0069
  • TCGA.02.0070
  • TCGA.02.0071
  • TCGA.02.0074
  • TCGA.02.0075
  • TCGA.02.0079
  • TCGA.02.0080
  • TCGA.02.0083
  • TCGA.02.0085
  • TCGA.02.0086
  • TCGA.02.0089
  • TCGA.02.0099
  • TCGA.02.0102
  • TCGA.02.0104
  • TCGA.02.0107
  • TCGA.02.0113
  • TCGA.02.0114
  • TCGA.02.0115
  • TCGA.02.0116
  • TCGA.02.0289
  • TCGA.02.0321
  • TCGA.02.0330
  • TCGA.02.0332
  • TCGA.02.0337
  • TCGA.02.0422
  • TCGA.02.0430
  • TCGA.02.0432
  • TCGA.02.0440
  • TCGA.02.0446
  • TCGA.02.2466
  • TCGA.02.2470
  • TCGA.02.2483
  • TCGA.02.2485
  • TCGA.02.2486
  • TCGA.06.0122
  • TCGA.06.0124
  • TCGA.06.0125
  • TCGA.06.0126
  • TCGA.06.0128
  • TCGA.06.0129
  • TCGA.06.0130
  • TCGA.06.0132
  • TCGA.06.0133
  • TCGA.06.0137
  • TCGA.06.0138
  • TCGA.06.0139
  • TCGA.06.0140
  • TCGA.06.0141
  • TCGA.06.0142
  • TCGA.06.0143
  • TCGA.06.0145
  • TCGA.06.0146
  • TCGA.06.0148
  • TCGA.06.0150
  • TCGA.06.0151
  • TCGA.06.0152
  • TCGA.06.0154
  • TCGA.06.0155
  • TCGA.06.0156
  • TCGA.06.0157
  • TCGA.06.0158
  • TCGA.06.0159
  • TCGA.06.0160
  • TCGA.06.0165
  • TCGA.06.0166
  • TCGA.06.0167
  • TCGA.06.0168
  • TCGA.06.0169
  • TCGA.06.0171
  • TCGA.06.0173
  • TCGA.06.0174
  • TCGA.06.0176
  • TCGA.06.0178
  • TCGA.06.0184
  • TCGA.06.0185
  • TCGA.06.0187
  • TCGA.06.0188
  • TCGA.06.0189
  • TCGA.06.0190
  • TCGA.06.0192
  • TCGA.06.0195
  • TCGA.06.0197
  • TCGA.06.0201
  • TCGA.06.0206
  • TCGA.06.0208
  • TCGA.06.0209
  • TCGA.06.0210
  • TCGA.06.0211
  • TCGA.06.0213
  • TCGA.06.0214
  • TCGA.06.0216
  • TCGA.06.0219
  • TCGA.06.0221
  • TCGA.06.0237
  • TCGA.06.0238
  • TCGA.06.0240
  • TCGA.06.0241
  • TCGA.06.0394
  • TCGA.06.0409
  • TCGA.06.0644
  • TCGA.06.0649
  • TCGA.06.0650
  • TCGA.06.0673
  • TCGA.06.0675
  • TCGA.06.0676
  • TCGA.06.0678
  • TCGA.06.0681
  • TCGA.06.0686
  • TCGA.06.0743
  • TCGA.06.0744
  • TCGA.06.0745
  • TCGA.06.0747
  • TCGA.06.0749
  • TCGA.06.0750
  • TCGA.06.0875
  • TCGA.06.0876
  • TCGA.06.0877
  • TCGA.06.0878
  • TCGA.06.0879
  • TCGA.06.0881
  • TCGA.06.0882
  • TCGA.06.1084
  • TCGA.06.1086
  • TCGA.06.1087
  • TCGA.06.1800
  • TCGA.06.1801
  • TCGA.06.1802
  • TCGA.06.1804
  • TCGA.06.1805
  • TCGA.06.2557
  • TCGA.06.2558
  • TCGA.06.2559
  • TCGA.06.2561
  • TCGA.06.2562
  • TCGA.06.2563
  • TCGA.06.2564
  • TCGA.06.2565
  • TCGA.06.2566
  • TCGA.06.2567
  • TCGA.06.2570
  • TCGA.06.5412
  • TCGA.06.5414
  • TCGA.06.5415
  • TCGA.06.5417
  • TCGA.06.5418
  • TCGA.06.5856
  • TCGA.06.5859
  • TCGA.06.6388
  • TCGA.06.6390
  • TCGA.06.6695
  • TCGA.06.6697
  • TCGA.06.6698
  • TCGA.06.6699
  • TCGA.06.6701
  • TCGA.08.0244
  • TCGA.08.0245
  • TCGA.08.0246
  • TCGA.08.0344
  • TCGA.08.0346
  • TCGA.08.0347
  • TCGA.08.0348
  • TCGA.08.0350
  • TCGA.08.0351
  • TCGA.08.0353
  • TCGA.08.0354
  • TCGA.08.0355
  • TCGA.08.0356
  • TCGA.08.0357
  • TCGA.08.0359
  • TCGA.08.0360
  • TCGA.08.0380
  • TCGA.08.0385
  • TCGA.08.0389
  • TCGA.08.0390
  • TCGA.08.0392
  • TCGA.08.0510
  • TCGA.08.0512
  • TCGA.08.0517
  • TCGA.08.0524
  • TCGA.08.0623
  • TCGA.08.0625
  • TCGA.08.0626
  • TCGA.08.0627
  • TCGA.12.0616
  • TCGA.12.0618
  • TCGA.12.0619
  • TCGA.12.0620
  • TCGA.12.0653
  • TCGA.12.0654
  • TCGA.12.0656
  • TCGA.12.0657
  • TCGA.12.0662
  • TCGA.12.0670
  • TCGA.12.0688
  • TCGA.12.0691
  • TCGA.12.0692
  • TCGA.12.0703
  • TCGA.12.0707
  • TCGA.12.0769
  • TCGA.12.0772
  • TCGA.12.0773
  • TCGA.12.0775
  • TCGA.12.0776
  • TCGA.12.0778
  • TCGA.12.0780
  • TCGA.12.0818
  • TCGA.12.0819
  • TCGA.12.0820
  • TCGA.12.0821
  • TCGA.12.0822
  • TCGA.12.0826
  • TCGA.12.0827
  • TCGA.12.0828
  • TCGA.12.0829
  • TCGA.12.1088
  • TCGA.12.1089
  • TCGA.12.1091
  • TCGA.12.1092
  • TCGA.12.1093
  • TCGA.12.1094
  • TCGA.12.1095
  • TCGA.12.1097
  • TCGA.12.1098
  • TCGA.12.1099
  • TCGA.12.1599
  • TCGA.12.1600
  • TCGA.12.1602
  • TCGA.12.3646
  • TCGA.12.3649
  • TCGA.12.5295
  • TCGA.14.0736
  • TCGA.14.0781
  • TCGA.14.0783
  • TCGA.14.0787
  • TCGA.14.0789
  • TCGA.14.0790
  • TCGA.14.0812
  • TCGA.14.0813
  • TCGA.14.0817
  • TCGA.14.0865
  • TCGA.14.0867
  • TCGA.14.1034
  • TCGA.14.1037
  • TCGA.14.1043
  • TCGA.14.1396
  • TCGA.14.1401
  • TCGA.14.1402
  • TCGA.14.1450
  • TCGA.14.1451
  • TCGA.14.1452
  • TCGA.14.1453
  • TCGA.14.1454
  • TCGA.14.1456
  • TCGA.14.1458
  • TCGA.14.1459
  • TCGA.14.1827
  • TCGA.14.1829
  • TCGA.14.2554
  • TCGA.14.3476
  • TCGA.14.4157
  • TCGA.15.0742
  • TCGA.15.1446
  • TCGA.15.1447
  • TCGA.15.1449
  • TCGA.16.0846
  • TCGA.16.0848
  • TCGA.16.0849
  • TCGA.16.0850
  • TCGA.16.0861
  • TCGA.16.1045
  • TCGA.16.1047
  • TCGA.16.1055
  • TCGA.16.1056
  • TCGA.16.1060
  • TCGA.16.1062
  • TCGA.16.1063
  • TCGA.19.0955
  • TCGA.19.0957
  • TCGA.19.0960
  • TCGA.19.0963
  • TCGA.19.0964
  • TCGA.19.1387
  • TCGA.19.1390
  • TCGA.19.1392
  • TCGA.19.1787
  • TCGA.19.1790
  • TCGA.19.2619
  • TCGA.19.2625
  • TCGA.19.2629
  • TCGA.19.2631
  • TCGA.19.5947
  • TCGA.19.5951
  • TCGA.19.5953
  • TCGA.19.5954
  • TCGA.19.5955
  • TCGA.19.5956
  • TCGA.19.5959
  • TCGA.26.1438
  • TCGA.26.1439
  • TCGA.26.1440
  • TCGA.26.1442
  • TCGA.26.1443
  • TCGA.26.5133
  • TCGA.26.5134
  • TCGA.26.5135
  • TCGA.26.5136
  • TCGA.26.5139
  • TCGA.26.6173
  • TCGA.27.1833
  • TCGA.27.1836
  • TCGA.27.1837
  • TCGA.27.1838
  • TCGA.27.2518
  • TCGA.27.2519
  • TCGA.27.2521
  • TCGA.27.2523
  • TCGA.27.2526
  • TCGA.27.2527
  • TCGA.27.2528
  • TCGA.28.1745
  • TCGA.28.1746
  • TCGA.28.1747
  • TCGA.28.1751
  • TCGA.28.1753
  • TCGA.28.1755
  • TCGA.28.1756
  • TCGA.28.2506
  • TCGA.28.2509
  • TCGA.28.2510
  • TCGA.28.2513
  • TCGA.28.2514
  • TCGA.28.5208
  • TCGA.28.5209
  • TCGA.28.5213
  • TCGA.28.5214
  • TCGA.28.5220
  • TCGA.28.6450
  • TCGA.32.1970
  • TCGA.32.1973
  • TCGA.32.1986
  • TCGA.32.1987
  • TCGA.32.1991
  • TCGA.32.2491
  • TCGA.32.2494
  • TCGA.32.2495
  • TCGA.32.2615
  • TCGA.32.4208
  • TCGA.32.4209
  • TCGA.32.4210
  • TCGA.32.4211
  • TCGA.32.4719
  • TCGA.41.2572
  • TCGA.41.2573
  • TCGA.41.2575
  • TCGA.41.3393
  • TCGA.41.3915
  • TCGA.41.4097
  • TCGA.41.5651
  • TCGA.74.6573
  • TCGA.74.6575
  • TCGA.74.6578
  • TCGA.76.4925
  • TCGA.76.4927
  • TCGA.76.4932
  • TCGA.76.4934
  • TCGA.76.4935
  • TCGA.76.6191
  • TCGA.76.6282
  • TCGA.76.6286
  • TCGA.76.6657
  • TCGA.76.6660
  • TCGA.76.6661
  • TCGA.76.6664
  • TCGA.81.5910
  • TCGA.81.5911
  • TCGA.87.5896

Regulators

TypeNameActionPrior Knowledge
TFIRF1
Activator
Yes
TFIKZF1
Activator
Yes

Causal Flows

MutationRegulatorBicluster
DNAH5IKZF1TFBS_DB_326
EPHA2_FORWARD_SIGNALINGIRF1TFBS_DB_326
FGF_SIGNALING_PATHWAYIRF1TFBS_DB_326
IL1_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_326
IL3_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_326
IL5_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_326
IL6_MEDIATED_SIGNALING_EVENTSIRF1TFBS_DB_326
NONGENOTROPIC_ANDROGEN_SIGNALINGIRF1TFBS_DB_326
PLASMA_MEMBRANE_ESTROGEN_RECEPTOR_SIGNALINGIRF1TFBS_DB_326
REELIN_SIGNALING_PATHWAYIRF1TFBS_DB_326
SIGNALING_EVENTS_REGULATED_BY_RET_TYROSINE_KINASEIRF1TFBS_DB_326
VEGFR1_SPECIFIC_SIGNALSIRF1TFBS_DB_326

Enriched GO Biological Processes

GO TermGO BP IDGenes
Cell activationGO:0001775
Cytokine productionGO:0001816
Response to molecule of bacterial originGO:0002237
Immune effector processGO:0002252
Activation of immune responseGO:0002253
Cell activation involved in immune responseGO:0002263
Myeloid leukocyte activationGO:0002274
Myeloid cell activation involved in immune responseGO:0002275
Leukocyte activation involved in immune responseGO:0002366
Immune system processGO:0002376CD300LF
Immune response-activating cell surface receptor signaling pathwayGO:0002429
Leukocyte mediated immunityGO:0002443
Antigen processing and presentation of exogenous peptide antigenGO:0002478
Antigen processing and presentation of peptide antigen via mhc class iiGO:0002495
Antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:0002504HLA-DRA
Regulation of immune system processGO:0002682
Positive regulation of immune system processGO:0002684
Regulation of leukocyte activationGO:0002694
Immune response-activating signal transductionGO:0002757
Immune response-regulating signaling pathwayGO:0002764
Immune response-regulating cell surface receptor signaling pathwayGO:0002768
Response to stressGO:0006950
Defense responseGO:0006952CD74 CXCL9
Inflammatory responseGO:0006954CCR5 CXCL9 CYBB GBP5 HCK LGALS9 NCF1 NLRC4 SLC11A1 STAB1 TLR1 TLR2 TLR3
Immune responseGO:0006955ADAMDEC1 CCR5 CIITA CXCL9 HLA-DOA HLA-DPA1 HLA-DRA LCP2 TLR1 TLR2 TRIM22
Cellular defense responseGO:0006968CCR5 CXCL9 MNDA NCF1 NCF2
Detection of biotic stimulusGO:0009595
Response to biotic stimulusGO:0009607
Response to woundingGO:0009611
Response to bacteriumGO:0009617SLC11A1
Response to organic substanceGO:0010033
Detection of bacteriumGO:0016045NLRC4
Cytokine-mediated signaling pathwayGO:0019221CIITA HCK HLA-DPA1 HLA-DRA TRIM22 UBE2L6
Antigen processing and presentationGO:0019882
Antigen processing and presentation of exogenous antigenGO:0019884
Antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:0019886CD74 FCER1G HLA-DMA HLA-DOA HLA-DPA1 HLA-DRA
Lymphocyte costimulationGO:0031294
T cell costimulationGO:0031295HLA-DPA1 HLA-DRA
Positive regulation of defense responseGO:0031349
Positive regulation of response to external stimulusGO:0032103
Response to lipopolysaccharideGO:0032496CXCL9 EDNRA LGALS9 SLC11A1
Interleukin-6 productionGO:0032635
Tumor necrosis factor productionGO:0032640
Regulation of interleukin-6 productionGO:0032675
Regulation of tumor necrosis factor productionGO:0032680
Positive regulation of interleukin-6 productionGO:0032755FCER1G TLR2 TLR3
Response to cytokine stimulusGO:0034097
Response to interferon-gammaGO:0034341CIITA SLC11A1
Modification of morphology or physiology of other organismGO:0035821
Macrophage activationGO:0042116SLC11A1 TLR1
Response to chemical stimulusGO:0042221
Detection of bacterial lipoproteinGO:0042494
Detection of triacyl bacterial lipopeptideGO:0042495TLR1 TLR2
Superoxide anion generationGO:0042554CYBB NCF1 NCF2
Defense response to bacteriumGO:0042742FCER1G NLRC4 SLAMF8 SLC11A1 STAB1 TLR3
Leukocyte degranulationGO:0043299HCK
Modification by symbiont of host morphology or physiologyGO:0044003
Symbiosis, encompassing mutualism through parasitismGO:0044403
Interspecies interaction between organismsGO:0044419
Positive thymic t cell selectionGO:0045059CD74 HLA-DMA
Innate immune responseGO:0045087CYBB CYFIP1 FCER1G HCK LCP2 NCF1 NCF2 NLRC4 TLR1 TLR2 TLR3 TNFAIP8L2 TREM2 UBE2L6
Leukocyte activationGO:0045321
Respiratory burstGO:0045730CYBB NCF1 NCF2 SLC11A1
Antigen processing and presentation of peptide antigenGO:0048002SLC11A1
Positive regulation of response to stimulusGO:0048584
Positive regulation of inflammatory responseGO:0050729EDNRA TLR2 TLR3
Regulation of phagocytosisGO:0050764HCK ITGAV
Positive regulation of phagocytosisGO:0050766FCER1G SLC11A1
Regulation of immune responseGO:0050776CD300LF TREM2
Positive regulation of immune responseGO:0050778HLA-DMA
Antigen receptor-mediated signaling pathwayGO:0050851
T cell receptor signaling pathwayGO:0050852HLA-DPA1 HLA-DRA LCP2
Chaperone mediated protein folding requiring cofactorGO:0051085CD74 HLA-DMA
Interaction with hostGO:0051701
Multi-organism processGO:0051704
Response to other organismGO:0051707
Modification of morphology or physiology of other organism involved in symbiotic interactionGO:0051817
Modulation by symbiont of host defense responseGO:0052031
Pathogen-associated molecular pattern dependent induction by symbiont of host innate immunityGO:0052033
Positive regulation by symbiont of host innate immunityGO:0052166
Modulation by symbiont of host innate immunityGO:0052167
Pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunityGO:0052169
Modulation by organism of defense response of other organism involved in symbiotic interactionGO:0052255
Pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interactionGO:0052257
Positive regulation by organism of innate immunity in other organism involved in symbiotic interactionGO:0052305
Modulation by organism of innate immunity in other organism involved in symbiotic interactionGO:0052306
Pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interactionGO:0052308
Positive regulation by symbiont of host defense responseGO:0052509
Positive regulation by organism of defense response of other organism involved in symbiotic interactionGO:0052510
Modulation by organism of immune response of other organism involved in symbiotic interactionGO:0052552
Modulation by symbiont of host immune responseGO:0052553
Positive regulation by organism of immune response of other organism involved in symbiotic interactionGO:0052555
Positive regulation by symbiont of host immune responseGO:0052556
Interferon-gamma-mediated signaling pathwayGO:0060333CIITA HCK HLA-DPA1 HLA-DRA TRIM22
Detection of bacterial lipopeptideGO:0070340
Cellular response to chemical stimulusGO:0070887
Cellular response to molecule of bacterial originGO:0071219
Cellular response to cytokine stimulusGO:0071345
Cellular response to interferon-gammaGO:0071346GBP5 HLA-DPA1 LGALS9 TLR3
Tumor necrosis factor superfamily cytokine productionGO:0071706
Response to triacyl bacterial lipopeptideGO:0071725
Cellular response to triacyl bacterial lipopeptideGO:0071727TLR1 TLR2

Enriched Hallmarks of Cancer

Enriched Hallmarks
  • Tumor promoting inflammation Tumor promoting inflammation
  • Evading immune detection Evading immune detection
Legend:
 
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011