Searched for:  ETV6

ETV6 mutations modulate:

List of mutations that drive a causal flow containing a regulator followed by a downstream bicluster. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
 

Mutations in ETV6 are not predicted modulate anything in gbmSYGNAL.
 

ETV6 regulates:

List of biclusters regulated by the regulator that was searched. Next to the regulator in parentheses is the regulators mechanism of action (Act. = activator and Rep. = repressor). Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
RegulatorRegulated Biclusters
ETV67
Regulator (Action)BiclusterSurvival (p-value)Hallmark(s)
ETV6 (Rep.)PITA_711.98 (4.7E-02)
ETV6 (Rep.)TARGETSCAN_92.71 (6.7E-03)
ETV6 (Rep.)TARGETSCAN_3282.96 (3.1E-03)
ETV6 (Rep.)TARGETSCAN_3913.41 (6.5E-04)
ETV6 (Rep.)TARGETSCAN_4563.28 (1.0E-03)
ETV6 (Rep.)TARGETSCAN_4844.35 (1.4E-05)
ETV6 (Rep.)TARGETSCAN_5303.06 (2.2E-03)Evading apoptosis

Biclusters containing ETV6:

List of biclusters that contain the genes that was searched. Var. Exp. FPC is the variance explained by the first principal component and is a good measure of bicluster co-expression. Survival is the Cox proportional hazards regression of the bicluster eigengene versus paitent survival. Hallmark(s) is the hallmarks of cancer associated with the bicluster genes. Legend for hallmarks:
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011
GeneBiclusters
ETV68
BiclusterVar. Exp. FPC
(Perm. p-value)
Survival
(p-value)
Hallmark(s)
PITA_240.51 (0.0)3.71163 (0.00021)
PITA_1150.55 (0.0)3.87422 (0.00011)
TARGETSCAN_600.54 (0.0)3.87843 (0.00011)
TARGETSCAN_1710.44 (0.0)2.96956 (0.003)Tissue invasion and metastasis
TFBS_DB_1810.54 (0.0)3.68348 (0.00023)
TFBS_DB_3860.49 (0.0)3.80656 (0.00014)
TFBS_DB_5230.39 (0.0)3.60914 (0.00031)
TFBS_DB_5460.42 (0.0)3.41816 (0.00063)