TFBS_DB_168

Bicluster Network Summary

Legend:
= Somatically mutated gene/pathway
= TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer

Summary

Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype.
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment.
GenesPatient TumorsFPC Var. Exp.
(Perm. p-value)
Survival
(p-value)
Independent Replication
16412
0.74 (0.0E+00)
2.53 (1.1E-02)
Co-expression
Survival
RegulatorsCausal FlowsEnriched GO BPsEnriched
Hallmarks of Cancer
121024

Replication in independent datasets

StudyFPC Var. Exp. (Perm. p-value)Survival (p-value)
Gravendeel, et al. 2009
0.69 (0.0E+00)
2.97 (3.0E-03)
Madhavan, et al. 2009
0.73 (0.0E+00)
2.17 (3.0E-02)
Murat, et al. 2008
0.73 (0.0E+00)
-0.91 (3.6E-01)

Patients

  • TCGA.02.0001
  • TCGA.02.0003
  • TCGA.02.0004
  • TCGA.02.0006
  • TCGA.02.0007
  • TCGA.02.0009
  • TCGA.02.0010
  • TCGA.02.0011
  • TCGA.02.0014
  • TCGA.02.0015
  • TCGA.02.0016
  • TCGA.02.0021
  • TCGA.02.0023
  • TCGA.02.0024
  • TCGA.02.0025
  • TCGA.02.0026
  • TCGA.02.0027
  • TCGA.02.0028
  • TCGA.02.0033
  • TCGA.02.0034
  • TCGA.02.0037
  • TCGA.02.0038
  • TCGA.02.0039
  • TCGA.02.0043
  • TCGA.02.0046
  • TCGA.02.0047
  • TCGA.02.0048
  • TCGA.02.0051
  • TCGA.02.0052
  • TCGA.02.0054
  • TCGA.02.0055
  • TCGA.02.0057
  • TCGA.02.0058
  • TCGA.02.0059
  • TCGA.02.0060
  • TCGA.02.0064
  • TCGA.02.0068
  • TCGA.02.0069
  • TCGA.02.0070
  • TCGA.02.0071
  • TCGA.02.0074
  • TCGA.02.0075
  • TCGA.02.0079
  • TCGA.02.0080
  • TCGA.02.0083
  • TCGA.02.0085
  • TCGA.02.0086
  • TCGA.02.0089
  • TCGA.02.0099
  • TCGA.02.0102
  • TCGA.02.0104
  • TCGA.02.0107
  • TCGA.02.0113
  • TCGA.02.0114
  • TCGA.02.0115
  • TCGA.02.0116
  • TCGA.02.0289
  • TCGA.02.0321
  • TCGA.02.0330
  • TCGA.02.0332
  • TCGA.02.0337
  • TCGA.02.0422
  • TCGA.02.0430
  • TCGA.02.0432
  • TCGA.02.0440
  • TCGA.02.0446
  • TCGA.02.2466
  • TCGA.02.2470
  • TCGA.02.2483
  • TCGA.02.2485
  • TCGA.02.2486
  • TCGA.06.0122
  • TCGA.06.0124
  • TCGA.06.0125
  • TCGA.06.0126
  • TCGA.06.0128
  • TCGA.06.0129
  • TCGA.06.0130
  • TCGA.06.0132
  • TCGA.06.0133
  • TCGA.06.0137
  • TCGA.06.0138
  • TCGA.06.0139
  • TCGA.06.0140
  • TCGA.06.0141
  • TCGA.06.0142
  • TCGA.06.0143
  • TCGA.06.0145
  • TCGA.06.0146
  • TCGA.06.0148
  • TCGA.06.0150
  • TCGA.06.0151
  • TCGA.06.0152
  • TCGA.06.0154
  • TCGA.06.0155
  • TCGA.06.0156
  • TCGA.06.0157
  • TCGA.06.0158
  • TCGA.06.0159
  • TCGA.06.0160
  • TCGA.06.0165
  • TCGA.06.0166
  • TCGA.06.0167
  • TCGA.06.0168
  • TCGA.06.0169
  • TCGA.06.0171
  • TCGA.06.0173
  • TCGA.06.0174
  • TCGA.06.0176
  • TCGA.06.0178
  • TCGA.06.0184
  • TCGA.06.0185
  • TCGA.06.0187
  • TCGA.06.0188
  • TCGA.06.0189
  • TCGA.06.0190
  • TCGA.06.0192
  • TCGA.06.0195
  • TCGA.06.0197
  • TCGA.06.0201
  • TCGA.06.0206
  • TCGA.06.0208
  • TCGA.06.0209
  • TCGA.06.0210
  • TCGA.06.0211
  • TCGA.06.0213
  • TCGA.06.0214
  • TCGA.06.0216
  • TCGA.06.0219
  • TCGA.06.0221
  • TCGA.06.0237
  • TCGA.06.0238
  • TCGA.06.0240
  • TCGA.06.0241
  • TCGA.06.0394
  • TCGA.06.0409
  • TCGA.06.0644
  • TCGA.06.0649
  • TCGA.06.0650
  • TCGA.06.0673
  • TCGA.06.0675
  • TCGA.06.0676
  • TCGA.06.0678
  • TCGA.06.0681
  • TCGA.06.0686
  • TCGA.06.0743
  • TCGA.06.0744
  • TCGA.06.0745
  • TCGA.06.0747
  • TCGA.06.0750
  • TCGA.06.0875
  • TCGA.06.0876
  • TCGA.06.0877
  • TCGA.06.0878
  • TCGA.06.0879
  • TCGA.06.0881
  • TCGA.06.0882
  • TCGA.06.1084
  • TCGA.06.1086
  • TCGA.06.1800
  • TCGA.06.1801
  • TCGA.06.1802
  • TCGA.06.1804
  • TCGA.06.1805
  • TCGA.06.2557
  • TCGA.06.2558
  • TCGA.06.2559
  • TCGA.06.2561
  • TCGA.06.2562
  • TCGA.06.2563
  • TCGA.06.2564
  • TCGA.06.2565
  • TCGA.06.2566
  • TCGA.06.2567
  • TCGA.06.2570
  • TCGA.06.5412
  • TCGA.06.5414
  • TCGA.06.5415
  • TCGA.06.5417
  • TCGA.06.5418
  • TCGA.06.5856
  • TCGA.06.5859
  • TCGA.06.6388
  • TCGA.06.6390
  • TCGA.06.6695
  • TCGA.06.6697
  • TCGA.06.6698
  • TCGA.06.6699
  • TCGA.06.6701
  • TCGA.08.0244
  • TCGA.08.0245
  • TCGA.08.0246
  • TCGA.08.0344
  • TCGA.08.0346
  • TCGA.08.0347
  • TCGA.08.0348
  • TCGA.08.0350
  • TCGA.08.0351
  • TCGA.08.0353
  • TCGA.08.0354
  • TCGA.08.0355
  • TCGA.08.0356
  • TCGA.08.0357
  • TCGA.08.0359
  • TCGA.08.0360
  • TCGA.08.0380
  • TCGA.08.0385
  • TCGA.08.0389
  • TCGA.08.0390
  • TCGA.08.0392
  • TCGA.08.0510
  • TCGA.08.0512
  • TCGA.08.0517
  • TCGA.08.0524
  • TCGA.08.0623
  • TCGA.08.0625
  • TCGA.08.0626
  • TCGA.08.0627
  • TCGA.12.0616
  • TCGA.12.0618
  • TCGA.12.0619
  • TCGA.12.0620
  • TCGA.12.0653
  • TCGA.12.0654
  • TCGA.12.0656
  • TCGA.12.0657
  • TCGA.12.0662
  • TCGA.12.0670
  • TCGA.12.0688
  • TCGA.12.0691
  • TCGA.12.0692
  • TCGA.12.0703
  • TCGA.12.0707
  • TCGA.12.0769
  • TCGA.12.0772
  • TCGA.12.0773
  • TCGA.12.0775
  • TCGA.12.0776
  • TCGA.12.0778
  • TCGA.12.0780
  • TCGA.12.0818
  • TCGA.12.0819
  • TCGA.12.0820
  • TCGA.12.0821
  • TCGA.12.0822
  • TCGA.12.0826
  • TCGA.12.0827
  • TCGA.12.0828
  • TCGA.12.0829
  • TCGA.12.1088
  • TCGA.12.1089
  • TCGA.12.1090
  • TCGA.12.1091
  • TCGA.12.1092
  • TCGA.12.1093
  • TCGA.12.1094
  • TCGA.12.1095
  • TCGA.12.1097
  • TCGA.12.1098
  • TCGA.12.1099
  • TCGA.12.1599
  • TCGA.12.1600
  • TCGA.12.1602
  • TCGA.12.3646
  • TCGA.12.3649
  • TCGA.12.5295
  • TCGA.14.0736
  • TCGA.14.0781
  • TCGA.14.0783
  • TCGA.14.0787
  • TCGA.14.0789
  • TCGA.14.0790
  • TCGA.14.0812
  • TCGA.14.0813
  • TCGA.14.0817
  • TCGA.14.0865
  • TCGA.14.0867
  • TCGA.14.0871
  • TCGA.14.1034
  • TCGA.14.1037
  • TCGA.14.1043
  • TCGA.14.1396
  • TCGA.14.1401
  • TCGA.14.1402
  • TCGA.14.1450
  • TCGA.14.1451
  • TCGA.14.1452
  • TCGA.14.1453
  • TCGA.14.1454
  • TCGA.14.1456
  • TCGA.14.1458
  • TCGA.14.1459
  • TCGA.14.1827
  • TCGA.14.1829
  • TCGA.14.2554
  • TCGA.14.4157
  • TCGA.15.0742
  • TCGA.15.1446
  • TCGA.15.1447
  • TCGA.15.1449
  • TCGA.16.0846
  • TCGA.16.0848
  • TCGA.16.0849
  • TCGA.16.0850
  • TCGA.16.0861
  • TCGA.16.1045
  • TCGA.16.1047
  • TCGA.16.1055
  • TCGA.16.1056
  • TCGA.16.1060
  • TCGA.16.1062
  • TCGA.16.1063
  • TCGA.19.0955
  • TCGA.19.0957
  • TCGA.19.0960
  • TCGA.19.0963
  • TCGA.19.0964
  • TCGA.19.1387
  • TCGA.19.1390
  • TCGA.19.1392
  • TCGA.19.1787
  • TCGA.19.1790
  • TCGA.19.1791
  • TCGA.19.2619
  • TCGA.19.2625
  • TCGA.19.2629
  • TCGA.19.2631
  • TCGA.19.5947
  • TCGA.19.5951
  • TCGA.19.5953
  • TCGA.19.5954
  • TCGA.19.5955
  • TCGA.19.5956
  • TCGA.19.5959
  • TCGA.26.1438
  • TCGA.26.1439
  • TCGA.26.1440
  • TCGA.26.1442
  • TCGA.26.1443
  • TCGA.26.5133
  • TCGA.26.5134
  • TCGA.26.5135
  • TCGA.26.5136
  • TCGA.26.5139
  • TCGA.26.6173
  • TCGA.27.1833
  • TCGA.27.1836
  • TCGA.27.1837
  • TCGA.27.1838
  • TCGA.27.2518
  • TCGA.27.2519
  • TCGA.27.2521
  • TCGA.27.2523
  • TCGA.27.2526
  • TCGA.27.2527
  • TCGA.27.2528
  • TCGA.28.1745
  • TCGA.28.1746
  • TCGA.28.1747
  • TCGA.28.1751
  • TCGA.28.1753
  • TCGA.28.1755
  • TCGA.28.1756
  • TCGA.28.2506
  • TCGA.28.2509
  • TCGA.28.2510
  • TCGA.28.2513
  • TCGA.28.2514
  • TCGA.28.5208
  • TCGA.28.5209
  • TCGA.28.5213
  • TCGA.28.5214
  • TCGA.28.5220
  • TCGA.28.6450
  • TCGA.32.1970
  • TCGA.32.1973
  • TCGA.32.1986
  • TCGA.32.1987
  • TCGA.32.1991
  • TCGA.32.2491
  • TCGA.32.2494
  • TCGA.32.2495
  • TCGA.32.2615
  • TCGA.32.4208
  • TCGA.32.4209
  • TCGA.32.4210
  • TCGA.32.4211
  • TCGA.32.4719
  • TCGA.41.2572
  • TCGA.41.2573
  • TCGA.41.2575
  • TCGA.41.3393
  • TCGA.41.3915
  • TCGA.41.4097
  • TCGA.41.5651
  • TCGA.74.6573
  • TCGA.74.6575
  • TCGA.74.6578
  • TCGA.76.4925
  • TCGA.76.4927
  • TCGA.76.4932
  • TCGA.76.4934
  • TCGA.76.4935
  • TCGA.76.6191
  • TCGA.76.6282
  • TCGA.76.6286
  • TCGA.76.6657
  • TCGA.76.6660
  • TCGA.76.6661
  • TCGA.76.6664
  • TCGA.81.5911
  • TCGA.87.5896

Regulators

TypeNameActionPrior Knowledge
TFELF1
Activator
Yes

Causal Flows

MutationRegulatorBicluster
IL6_MEDIATED_SIGNALING_EVENTSELF1TFBS_DB_168
SIGNALING_EVENTS_MEDIATED_BY_THE_HEDGEHOG_FAMILYELF1TFBS_DB_168

Enriched GO Biological Processes

GO TermGO BP IDGenes
Cell activationGO:0001775
Positive regulation of protein phosphorylationGO:0001934AIF1
Immune effector processGO:0002252
Activation of immune responseGO:0002253
Cell activation involved in immune responseGO:0002263
Myeloid leukocyte activationGO:0002274
Myeloid cell activation involved in immune responseGO:0002275
Mast cell activation involved in immune responseGO:0002279
Leukocyte activation involved in immune responseGO:0002366SYK
Immune system processGO:0002376
Immune response-activating cell surface receptor signaling pathwayGO:0002429
Myeloid leukocyte mediated immunityGO:0002444
Mast cell mediated immunityGO:0002448
Production of molecular mediator involved in inflammatory responseGO:0002532
Monocyte chemotaxisGO:0002548
Regulation of immune system processGO:0002682
Positive regulation of immune system processGO:0002684
Regulation of leukocyte activationGO:0002694
Positive regulation of leukocyte activationGO:0002696
Regulation of immune effector processGO:0002697
Positive regulation of immune effector processGO:0002699
Immune response-activating signal transductionGO:0002757
Immune response-regulating signaling pathwayGO:0002764
Immune response-regulating cell surface receptor signaling pathwayGO:0002768LYN
Regulation of myeloid leukocyte mediated immunityGO:0002886
Leukotriene metabolic processGO:0006691ALOX5
Response to stressGO:0006950
Defense responseGO:0006952CSF3R LILRA2 LILRA3
Inflammatory responseGO:0006954AIF1 IL18
Immune responseGO:0006955CD4 IL18
Signal transductionGO:0007165APBB1IP CD4 CSF3R LILRA2 LILRA3 LYN
Regulation of platelet activationGO:0010543SYK
Positive regulation of phosphorus metabolic processGO:0010562
Leukotriene biosynthetic processGO:0019370ALOX5 SYK
Calcium-mediated signalingGO:0019722LAT2
Leukocyte chemotaxisGO:0030595
Granulocyte macrophage colony-stimulating factor productionGO:0032604
Regulation of granulocyte macrophage colony-stimulating factor productionGO:0032645
Regulation of superoxide anion generationGO:0032928SYK
Positive regulation of mononuclear cell proliferationGO:0032946
Regulation of mast cell activationGO:0033003LYN
Regulation of mast cell activation involved in immune responseGO:0033006
Cell adhesion mediated by integrinGO:0033627
Regulation of cell adhesion mediated by integrinGO:0033628LYN
Positive regulation of tissue remodelingGO:0034105IL18
Regulation of homotypic cell-cell adhesionGO:0034110
Cytokine biosynthetic processGO:0042089
Interleukin-2 biosynthetic processGO:0042094IL18
T cell proliferationGO:0042098
Positive regulation of t cell proliferationGO:0042102AIF1 CD4
Cytokine metabolic processGO:0042107
T cell activationGO:0042110
Regulation of t cell proliferationGO:0042129
Granulocyte macrophage colony-stimulating factor biosynthetic processGO:0042253IL18
Positive regulation of phosphorylationGO:0042327
Superoxide anion generationGO:0042554
Leukocyte degranulationGO:0043299
Regulation of leukocyte degranulationGO:0043300
Mast cell degranulationGO:0043303LAT2
Regulation of mast cell degranulationGO:0043304LYN
Cellular alkene metabolic processGO:0043449
Alkene biosynthetic processGO:0043450
Regulated secretory pathwayGO:0045055
T cell selectionGO:0045058CD4
Innate immune responseGO:0045087CD4 LAT2 LYN SYK
Leukocyte activationGO:0045321
Mast cell activationGO:0045576
Positive regulation of phosphate metabolic processGO:0045937
Alpha-beta t cell proliferationGO:0046633
Regulation of alpha-beta t cell proliferationGO:0046640
Positive regulation of alpha-beta t cell proliferationGO:0046641SYK
Lymphocyte activationGO:0046649
Regulation of response to stimulusGO:0048583
Positive regulation of lymphocyte proliferationGO:0050671
Regulation of peptidyl-tyrosine phosphorylationGO:0050730
Positive regulation of peptidyl-tyrosine phosphorylationGO:0050731CD4 SYK
Regulation of immune responseGO:0050776HCST
Positive regulation of immune responseGO:0050778
Regulation of biological processGO:0050789
Positive regulation of calcium-mediated signalingGO:0050850CD4 SYK
Antigen receptor-mediated signaling pathwayGO:0050851
B cell receptor signaling pathwayGO:0050853LAT2 LYN SYK
Regulation of t cell activationGO:0050863CD4
Regulation of cell activationGO:0050865
Positive regulation of cell activationGO:0050867
Positive regulation of t cell activationGO:0050870
Response to stimulusGO:0050896
Leukocyte migrationGO:0050900LYN
Regulation of lymphocyte activationGO:0051249
Positive regulation of lymphocyte activationGO:0051251
Cellular response to stimulusGO:0051716
Response to hyperoxiaGO:0055093ALOX5
Cell chemotaxisGO:0060326
Biological regulationGO:0065007
Platelet aggregationGO:0070527
Leukocyte proliferationGO:0070661
Regulation of leukocyte proliferationGO:0070663
Positive regulation of leukocyte proliferationGO:0070665
Cellular response to biotic stimulusGO:0071216
Regulation of monocyte chemotaxisGO:0090025LYN
Regulation of superoxide metabolic processGO:0090322
Regulation of platelet aggregationGO:0090330LYN SYK

Enriched Hallmarks of Cancer

Enriched Hallmarks
  • Tumor promoting inflammation Tumor promoting inflammation
  • Self sufficiency in growth signals Self sufficiency in growth signals
  • Evading immune detection Evading immune detection
  • Insensitivity to antigrowth signals Insensitivity to antigrowth signals
Legend:
 
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011