TARGETSCAN_454

Bicluster Network Summary

Legend:
= Somatically mutated gene/pathway
= TF; = miRNA; (Regulator edges: = Activation; T = Repression)
= Bicluster
= Hallmark of Cancer

Summary

Bicluster Expression of Patient Tumors
Expression of genes from patient tumors in bicluster on left side of red dashed line and out of bicluster on right of red dashed line. Each patient tumor is represented as a boxplot, ordered by their median expression for the bicluster genes (smallest to largest) and colored according to it's GBM subtype.
Enrichment of Tumor Subtypes in Qunitiles
Patient tumors are sorted as on the left and broken into quintiles following the dashed grey lines. Then each quintile is tested for enrichment of each tumor subtype. The deviation from zero indicate -log10(enrichment p-value), and positive values indicate over-enrichment and negative values underenrichment.
GenesPatient TumorsFPC Var. Exp.
(Perm. p-value)
Survival
(p-value)
Independent Replication
40386
0.42 (0.0E+00)
2.06 (3.9E-02)
Co-expression
Survival
RegulatorsCausal FlowsEnriched GO BPsEnriched
Hallmarks of Cancer
111112

Replication in independent datasets

StudyFPC Var. Exp. (Perm. p-value)Survival (p-value)
Gravendeel, et al. 2009
0.44 (0.0E+00)
2.48 (1.3E-02)
Madhavan, et al. 2009
0.48 (0.0E+00)
-2.71 (6.7E-03)
Murat, et al. 2008
0.42 (0.0E+00)
-1.09 (2.8E-01)

Patients

  • TCGA.02.0001
  • TCGA.02.0003
  • TCGA.02.0004
  • TCGA.02.0006
  • TCGA.02.0007
  • TCGA.02.0009
  • TCGA.02.0010
  • TCGA.02.0011
  • TCGA.02.0014
  • TCGA.02.0015
  • TCGA.02.0016
  • TCGA.02.0021
  • TCGA.02.0023
  • TCGA.02.0024
  • TCGA.02.0025
  • TCGA.02.0026
  • TCGA.02.0027
  • TCGA.02.0028
  • TCGA.02.0033
  • TCGA.02.0034
  • TCGA.02.0037
  • TCGA.02.0038
  • TCGA.02.0039
  • TCGA.02.0043
  • TCGA.02.0046
  • TCGA.02.0047
  • TCGA.02.0048
  • TCGA.02.0051
  • TCGA.02.0052
  • TCGA.02.0054
  • TCGA.02.0055
  • TCGA.02.0057
  • TCGA.02.0058
  • TCGA.02.0059
  • TCGA.02.0060
  • TCGA.02.0064
  • TCGA.02.0068
  • TCGA.02.0069
  • TCGA.02.0070
  • TCGA.02.0071
  • TCGA.02.0074
  • TCGA.02.0075
  • TCGA.02.0079
  • TCGA.02.0080
  • TCGA.02.0083
  • TCGA.02.0085
  • TCGA.02.0086
  • TCGA.02.0089
  • TCGA.02.0099
  • TCGA.02.0102
  • TCGA.02.0104
  • TCGA.02.0107
  • TCGA.02.0113
  • TCGA.02.0114
  • TCGA.02.0115
  • TCGA.02.0116
  • TCGA.02.0289
  • TCGA.02.0321
  • TCGA.02.0330
  • TCGA.02.0332
  • TCGA.02.0337
  • TCGA.02.0422
  • TCGA.02.0430
  • TCGA.02.0432
  • TCGA.02.0440
  • TCGA.02.0446
  • TCGA.02.2466
  • TCGA.02.2483
  • TCGA.02.2485
  • TCGA.02.2486
  • TCGA.06.0122
  • TCGA.06.0124
  • TCGA.06.0125
  • TCGA.06.0126
  • TCGA.06.0129
  • TCGA.06.0130
  • TCGA.06.0132
  • TCGA.06.0133
  • TCGA.06.0137
  • TCGA.06.0138
  • TCGA.06.0139
  • TCGA.06.0140
  • TCGA.06.0141
  • TCGA.06.0143
  • TCGA.06.0145
  • TCGA.06.0146
  • TCGA.06.0148
  • TCGA.06.0150
  • TCGA.06.0151
  • TCGA.06.0152
  • TCGA.06.0154
  • TCGA.06.0155
  • TCGA.06.0156
  • TCGA.06.0157
  • TCGA.06.0158
  • TCGA.06.0159
  • TCGA.06.0160
  • TCGA.06.0165
  • TCGA.06.0166
  • TCGA.06.0167
  • TCGA.06.0168
  • TCGA.06.0171
  • TCGA.06.0173
  • TCGA.06.0174
  • TCGA.06.0176
  • TCGA.06.0178
  • TCGA.06.0184
  • TCGA.06.0185
  • TCGA.06.0187
  • TCGA.06.0188
  • TCGA.06.0189
  • TCGA.06.0190
  • TCGA.06.0192
  • TCGA.06.0195
  • TCGA.06.0197
  • TCGA.06.0201
  • TCGA.06.0206
  • TCGA.06.0208
  • TCGA.06.0209
  • TCGA.06.0211
  • TCGA.06.0213
  • TCGA.06.0214
  • TCGA.06.0216
  • TCGA.06.0219
  • TCGA.06.0221
  • TCGA.06.0237
  • TCGA.06.0238
  • TCGA.06.0240
  • TCGA.06.0241
  • TCGA.06.0394
  • TCGA.06.0409
  • TCGA.06.0644
  • TCGA.06.0649
  • TCGA.06.0673
  • TCGA.06.0675
  • TCGA.06.0676
  • TCGA.06.0678
  • TCGA.06.0681
  • TCGA.06.0686
  • TCGA.06.0743
  • TCGA.06.0744
  • TCGA.06.0745
  • TCGA.06.0747
  • TCGA.06.0749
  • TCGA.06.0750
  • TCGA.06.0875
  • TCGA.06.0876
  • TCGA.06.0877
  • TCGA.06.0878
  • TCGA.06.0879
  • TCGA.06.0881
  • TCGA.06.0882
  • TCGA.06.1800
  • TCGA.06.1801
  • TCGA.06.1802
  • TCGA.06.1804
  • TCGA.06.2557
  • TCGA.06.2558
  • TCGA.06.2559
  • TCGA.06.2561
  • TCGA.06.2562
  • TCGA.06.2563
  • TCGA.06.2564
  • TCGA.06.2565
  • TCGA.06.2566
  • TCGA.06.2567
  • TCGA.06.2570
  • TCGA.06.5412
  • TCGA.06.5414
  • TCGA.06.5415
  • TCGA.06.5417
  • TCGA.06.5418
  • TCGA.06.5859
  • TCGA.06.6388
  • TCGA.06.6390
  • TCGA.06.6695
  • TCGA.06.6698
  • TCGA.06.6699
  • TCGA.08.0244
  • TCGA.08.0245
  • TCGA.08.0246
  • TCGA.08.0344
  • TCGA.08.0346
  • TCGA.08.0347
  • TCGA.08.0348
  • TCGA.08.0350
  • TCGA.08.0351
  • TCGA.08.0353
  • TCGA.08.0354
  • TCGA.08.0355
  • TCGA.08.0356
  • TCGA.08.0357
  • TCGA.08.0359
  • TCGA.08.0360
  • TCGA.08.0380
  • TCGA.08.0385
  • TCGA.08.0389
  • TCGA.08.0390
  • TCGA.08.0510
  • TCGA.08.0512
  • TCGA.08.0517
  • TCGA.08.0524
  • TCGA.08.0623
  • TCGA.08.0625
  • TCGA.08.0626
  • TCGA.08.0627
  • TCGA.12.0616
  • TCGA.12.0618
  • TCGA.12.0619
  • TCGA.12.0620
  • TCGA.12.0653
  • TCGA.12.0654
  • TCGA.12.0656
  • TCGA.12.0657
  • TCGA.12.0662
  • TCGA.12.0670
  • TCGA.12.0688
  • TCGA.12.0691
  • TCGA.12.0692
  • TCGA.12.0703
  • TCGA.12.0707
  • TCGA.12.0769
  • TCGA.12.0772
  • TCGA.12.0773
  • TCGA.12.0775
  • TCGA.12.0776
  • TCGA.12.0778
  • TCGA.12.0780
  • TCGA.12.0818
  • TCGA.12.0819
  • TCGA.12.0820
  • TCGA.12.0821
  • TCGA.12.0822
  • TCGA.12.0826
  • TCGA.12.0827
  • TCGA.12.0828
  • TCGA.12.0829
  • TCGA.12.1088
  • TCGA.12.1090
  • TCGA.12.1091
  • TCGA.12.1092
  • TCGA.12.1093
  • TCGA.12.1094
  • TCGA.12.1095
  • TCGA.12.1097
  • TCGA.12.1099
  • TCGA.12.1599
  • TCGA.12.1600
  • TCGA.12.1602
  • TCGA.12.3646
  • TCGA.12.3649
  • TCGA.14.0736
  • TCGA.14.0781
  • TCGA.14.0783
  • TCGA.14.0787
  • TCGA.14.0789
  • TCGA.14.0790
  • TCGA.14.0812
  • TCGA.14.0813
  • TCGA.14.0817
  • TCGA.14.0865
  • TCGA.14.0867
  • TCGA.14.1034
  • TCGA.14.1037
  • TCGA.14.1043
  • TCGA.14.1396
  • TCGA.14.1401
  • TCGA.14.1402
  • TCGA.14.1450
  • TCGA.14.1451
  • TCGA.14.1452
  • TCGA.14.1453
  • TCGA.14.1454
  • TCGA.14.1456
  • TCGA.14.1458
  • TCGA.14.1459
  • TCGA.14.2554
  • TCGA.14.3476
  • TCGA.14.4157
  • TCGA.15.0742
  • TCGA.15.1446
  • TCGA.15.1447
  • TCGA.15.1449
  • TCGA.16.0846
  • TCGA.16.0848
  • TCGA.16.0849
  • TCGA.16.0850
  • TCGA.16.0861
  • TCGA.16.1047
  • TCGA.16.1055
  • TCGA.16.1056
  • TCGA.16.1060
  • TCGA.16.1062
  • TCGA.16.1063
  • TCGA.19.0955
  • TCGA.19.0960
  • TCGA.19.0963
  • TCGA.19.0964
  • TCGA.19.1387
  • TCGA.19.1390
  • TCGA.19.1392
  • TCGA.19.1787
  • TCGA.19.1790
  • TCGA.19.1791
  • TCGA.19.2619
  • TCGA.19.2625
  • TCGA.19.2629
  • TCGA.19.2631
  • TCGA.19.5951
  • TCGA.19.5954
  • TCGA.19.5955
  • TCGA.19.5956
  • TCGA.19.5959
  • TCGA.26.1439
  • TCGA.26.1440
  • TCGA.26.1442
  • TCGA.26.5133
  • TCGA.26.5134
  • TCGA.26.5135
  • TCGA.26.5136
  • TCGA.26.5139
  • TCGA.26.6173
  • TCGA.27.1833
  • TCGA.27.1836
  • TCGA.27.1837
  • TCGA.27.1838
  • TCGA.27.2518
  • TCGA.27.2519
  • TCGA.27.2521
  • TCGA.27.2523
  • TCGA.27.2528
  • TCGA.28.1745
  • TCGA.28.1746
  • TCGA.28.1747
  • TCGA.28.1751
  • TCGA.28.1753
  • TCGA.28.1755
  • TCGA.28.1756
  • TCGA.28.2506
  • TCGA.28.2509
  • TCGA.28.2510
  • TCGA.28.2514
  • TCGA.28.5208
  • TCGA.28.5209
  • TCGA.28.5213
  • TCGA.28.5214
  • TCGA.28.5220
  • TCGA.28.6450
  • TCGA.32.1970
  • TCGA.32.1973
  • TCGA.32.1986
  • TCGA.32.1987
  • TCGA.32.1991
  • TCGA.32.2491
  • TCGA.32.2494
  • TCGA.32.2495
  • TCGA.32.2615
  • TCGA.32.4208
  • TCGA.32.4209
  • TCGA.32.4210
  • TCGA.32.4211
  • TCGA.32.4719
  • TCGA.41.2572
  • TCGA.41.2573
  • TCGA.41.2575
  • TCGA.41.3393
  • TCGA.41.3915
  • TCGA.41.4097
  • TCGA.41.5651
  • TCGA.74.6573
  • TCGA.74.6575
  • TCGA.74.6578
  • TCGA.76.4925
  • TCGA.76.4927
  • TCGA.76.4932
  • TCGA.76.4934
  • TCGA.76.4935
  • TCGA.76.6191
  • TCGA.76.6282
  • TCGA.76.6286
  • TCGA.76.6657
  • TCGA.76.6660
  • TCGA.76.6661
  • TCGA.76.6664
  • TCGA.81.5910
  • TCGA.87.5896

Regulators

TypeNameActionPrior Knowledge
TFELF1
Activator
Yes

Causal Flows

MutationRegulatorBicluster
NEUROTROPHIC_FACTOR_MEDIATED_TRK_RECEPTOR_SIGNALINGELF1TARGETSCAN_454

Enriched GO Biological Processes

GO TermGO BP IDGenes
Temperature homeostasisGO:0001659
Fever generationGO:0001660IL1B
Immune system processGO:0002376VSTM1
Chronic inflammatory response to antigenic stimulusGO:0002439IL1B TNF
Positive regulation of immune system processGO:0002684
Positive regulation of leukocyte migrationGO:0002687CCL8
Regulation of leukocyte chemotaxisGO:0002688
Positive regulation of leukocyte chemotaxisGO:0002690
Cellular calcium ion homeostasisGO:0006874CCL3 CCL8
Defense responseGO:0006952NLRP3
Inflammatory responseGO:0006954CCL3 CCL4 CCL8 IL1B NLRP3 TNF
Leukocyte cell-cell adhesionGO:0007159
Intracellular protein kinase cascadeGO:0007243
Cell-cell signalingGO:0007267ADRB2 CCL3 CCL4 CCL8 FGF20 IL1B SIRPG
Response to biotic stimulusGO:0009607
Response to woundingGO:0009611CX3CR1
Positive regulation of signal transductionGO:0009967
Positive regulation of cell communicationGO:0010647
Negative regulation of glucose transportGO:0010829IL1B
Cell migrationGO:0016477
Second-messenger-mediated signalingGO:0019932
Regulation of cell-cell adhesionGO:0022407
Positive regulation of cell-cell adhesionGO:0022409SIRPG
Positive regulation of signalingGO:0023056
Leukocyte chemotaxisGO:0030595
Sequestering of triglycerideGO:0030730IL1B TNF
Regulation of defense responseGO:0031347
Regulation of fever generationGO:0031620
Positive regulation of fever generationGO:0031622IL1B TNF
Heat generationGO:0031649ADRB2
Regulation of heat generationGO:0031650
Positive regulation of heat generationGO:0031652
Lipopolysaccharide-mediated signaling pathwayGO:0031663CCL3 IL1B TNF
Regulation of response to external stimulusGO:0032101
Positive regulation of response to external stimulusGO:0032103
Interleukin-1 beta productionGO:0032611IL1B NLRP3
Interleukin-1 productionGO:0032612
Interleukin-6 productionGO:0032635
Regulation of interleukin-1 beta productionGO:0032651
Regulation of interleukin-1 productionGO:0032652
Regulation of interleukin-6 productionGO:0032675
Positive regulation of monooxygenase activityGO:0032770
Regulation of localizationGO:0032879
Negative regulation of viral transcriptionGO:0032897
Heterotypic cell-cell adhesionGO:0034113GLDN
Regulation of heterotypic cell-cell adhesionGO:0034114
Positive regulation of heterotypic cell-cell adhesionGO:0034116IL1B TNF
Intracellular signal transductionGO:0035556MKNK1 PLCB2 SIRPG
Natural killer cell chemotaxisGO:0035747
LocomotionGO:0040011
Chemokine biosynthetic processGO:0042033
Regulation of nf-kappab import into nucleusGO:0042345
Nf-kappab import into nucleusGO:0042348
Regulation of transcription factor import into nucleusGO:0042990
Transcription factor import into nucleusGO:0042991
Regulation of ion transportGO:0043269
Positive regulation of ion transportGO:0043270P2RY12
Regulation of mapkkk cascadeGO:0043408
Positive regulation of mapkkk cascadeGO:0043410ADRB2
Protein kinase b signaling cascadeGO:0043491CCL3 IL1B P2RY12 TNF
Modulation by host of viral transcriptionGO:0043921
Negative regulation by host of viral transcriptionGO:0043922CCL3 CCL4
Regulation of chemokine biosynthetic processGO:0045073
Positive regulation of chemokine biosynthetic processGO:0045080IL1B TNF
Positive regulation of behaviorGO:0048520
Cell motilityGO:0048870
Regulation of interleukin-1 beta secretionGO:0050706
Regulation of cytokine secretionGO:0050707
Positive regulation of cytokine secretionGO:0050715TNF
Positive regulation of interleukin-1 beta secretionGO:0050718CCL3 NLRP3
Regulation of inflammatory responseGO:0050727
Positive regulation of inflammatory responseGO:0050729CCL3 CCL4 CCL8 PLA2G7
Chemokine metabolic processGO:0050755
Regulation of viral reproductionGO:0050792
Regulation of behaviorGO:0050795
Leukocyte migrationGO:0050900SELPLG SIRPG
Leukocyte tethering or rollingGO:0050901SELPLG TNF
Positive regulation of chemotaxisGO:0050921
Positive regulation of membrane protein ectodomain proteolysisGO:0051044IL1B TNF
Positive regulation of secretionGO:0051047
Regulation of transportGO:0051049
Positive regulation of transportGO:0051050
Negative regulation of transportGO:0051051
Positive regulation of protein transportGO:0051222TNF
Positive regulation of multicellular organismal processGO:0051240
Localization of cellGO:0051674
Multi-organism processGO:0051704
Response to other organismGO:0051707
Cellular response to stimulusGO:0051716
Modulation of transcription in other organism involved in symbiotic interactionGO:0052312
Modulation by host of symbiont transcriptionGO:0052472
Calcium ion homeostasisGO:0055074
Cell chemotaxisGO:0060326
Regulation of calcidiol 1-monooxygenase activityGO:0060558
Positive regulation of calcidiol 1-monooxygenase activityGO:0060559IL1B TNF
Erk1 and erk2 cascadeGO:0070371
Regulation of erk1 and erk2 cascadeGO:0070372
Positive regulation of erk1 and erk2 cascadeGO:0070374CCL3 CCL4 CCL8 FGF20 GPR120 IL1B TNF
Cell-cell adhesion involved in gastrulationGO:0070586
Regulation of cell-cell adhesion involved in gastrulationGO:0070587
Cellular response to chemical stimulusGO:0070887
Cellular response to biotic stimulusGO:0071216
Cellular response to molecule of bacterial originGO:0071219
Cellular response to lipopolysaccharideGO:0071222CX3CR1 NLRP3
Cellular response to organic cyclic compoundGO:0071407CCL3 IL1B P2RY13 TNF
Cellular divalent inorganic cation homeostasisGO:0072503
Divalent inorganic cation homeostasisGO:0072507
Negative regulation of reproductive processGO:2000242
Positive regulation of lymphocyte migrationGO:2000403
Regulation of natural killer cell chemotaxisGO:2000501
Positive regulation of natural killer cell chemotaxisGO:2000503CCL3 CCL4

Enriched Hallmarks of Cancer

Enriched Hallmarks
  • Self sufficiency in growth signals Self sufficiency in growth signals
  • Tissue invasion and metastasis Tissue invasion and metastasis
Legend:
 
Hallmarks of Cancer
Hanahan and Weinberg, Cell 2011